{
  "abstract": "An eco-friendly, base-free protocol was developed for the esterification of carboxylic acids with dimethyl carbonate (DMC), which serves as both the reagent and solvent, using an iron(iii) sulfate/H₂O catalytic system. The method combines high efficiency with a broad substrate scope under mild and environmentally benign conditions. Control experiments show that anhydrous Fe₂(SO₄)₃ is inactive and that water is required for activity. A tentative mechanism is proposed, in which water acts both as a reagent and as a source of in situ Brønsted acidity, a contribution of Lewis acidity not being excluded. Furthermore, our results highlight the plausible dual role of DMC, which may serve both as a sustainable source of methanol and as a chemical desiccant, thereby potentially shifting the equilibrium towards complete conversion. Overall, this protocol provides a green and cost-effective alternative to conventional Fischer esterification.",
  "abstract_shown": true,
  "affiliations": [
    "Laboratoire de Développement Chimique, Galénique et Pharmacologique des Médicaments, Faculté de Pharmacie de Monastir, Université de Monastir Rue Avicenne 5000 Monastir Tunisia jamil.kraiem@fphm.u-monastir.tn.",
    "Département de Chimie, Université Laval 1045 Avenue de La Médecine Québec Québec G1V 0A6 Canada thierry.ollevier@chm.ulaval.ca."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yosra Ben Abdallah"
    },
    {
      "affs": [
        0
      ],
      "name": "Zaineb Litim",
      "orcid": "0000-0002-6300-4901"
    },
    {
      "affs": [
        0
      ],
      "name": "Donia Ghedira"
    },
    {
      "affs": [
        1
      ],
      "name": "Thierry Ollevier",
      "orcid": "0000-0002-6084-7954"
    },
    {
      "affs": [
        0
      ],
      "name": "Jamil Kraïem",
      "orcid": "0000-0001-8917-1022"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/35cp1n239p33j.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra08238f",
  "fulltext_url": "https://europepmc.org/articles/PMC13679557",
  "id": "35cp1n239p33j",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898898",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1508|Carbon dioxide utilization in catalysis"
    ]
  ],
  "openalex": "W7222949143",
  "pdf_url": "https://europepmc.org/articles/PMC13679557?pdf=render",
  "pmcid": "PMC13679557",
  "pmid": "42898898",
  "published": "2026-10-19",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/35cp1n239p33j.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42898898",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898898"
    },
    {
      "first_seen": "2026-11-07T12:23:34Z",
      "native_id": "PMC13679557",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra08238f"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "heading:Chemistry",
      "subfield": "general"
    }
  ],
  "title": "Iron(iii) sulfate/H₂O-catalysed, base-free esterification of carboxylic acids with dimethyl carbonate: the crucial role of water as a co-catalyst.",
  "title_text": "Iron(iii) sulfate/H₂O-catalysed, base-free esterification of carboxylic acids with dimethyl carbonate: the crucial role of water as a co-catalyst.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:03Z",
  "url": "https://research.draconitic.com/paper/35cp1n239p33j",
  "venue": "RSC advances",
  "versions": []
}