{
  "abstract": "Background/Objectives: Randomized evidence for the oXiris adsorptive membrane in septic shock remains limited. We estimated its effect on 28-day mortality and explored short-term physiologic outcomes in adults with septic shock and acute kidney injury requiring continuous renal replacement therapy. Methods: PURE was a multicenter, single-blind, parallel-group pilot randomized trial in Saudi Arabia. Participants were randomized 1:1 to oXiris-based or conventional continuous venovenous hemodialysis. The primary comparison used unadjusted mortality risk estimates. Secondary observations were summarized descriptively; adjusted and post-hoc Bayesian sensitivity analyses are reported in the main text and supplement. Results: Of 204 randomized participants, 202 were analyzed (oXiris, 100; control, 102). Twenty-eight-day mortality was 39.0% (39/100) versus 47.1% (48/102), respectively (risk ratio, 0.83; 95% CI, 0.60–1.14; risk difference, −8.1 percentage points; 95% CI, −21.7 to 5.6; p = 0.247). Reported 72 h norepinephrine dose, lactate, C-reactive protein, and Sequential Organ Failure Assessment (SOFA) score were lower with oXiris; reported intensive care unit (ICU) stay was also shorter. Secondary descriptive observations are limited by unverifiable time-specific denominators and handling of intercurrent events. Premature filter clotting was reported in 8/100 versus 7/102 participants; no device-related adverse events were reported, but safety ascertainment was limited. Conclusions: This pilot trial did not demonstrate a statistically significant reduction in 28-day mortality, although mortality was numerically lower in the oXiris group. Consistent protocol implementation and encouraging, hypothesis-generating physiologic observations provide a foundation for a definitive trial with complete longitudinal ascertainment.",
  "abstract_shown": true,
  "affiliations": [
    "Critical Care Department, King Saud Medical City, Riyadh 11196, Saudi Arabia",
    "Department of Anesthesiology and Intensive Care, Faculty of Medicine, Tanta University, Tanta 31527, Egypt",
    "Critical Care Department, King Fahd Military Medical Complex, Dhahran 31932, Saudi Arabia",
    "Critical Care Department, Amna Inayat Medical College, Lahore 54000, Pakistan",
    "Critical Care Department, King Abdullah Specialized Hospital, National Guard Health Affairs, Buraidah 52569, Saudi Arabia",
    "Division of Nephrology, Bone and Mineral Metabolism, University of Kentucky, Lexington, KY 40506, USA",
    "Perioperative and Intensive Care, Skåne University Hospital, 222 42 Lund, Sweden"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 19,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ahmed Mady",
      "orcid": "0000-0002-9966-0839"
    },
    {
      "affs": [
        0
      ],
      "name": "Waleed Tharwat Aletreby",
      "orcid": "0000-0001-8387-1829"
    },
    {
      "affs": [
        2
      ],
      "name": "Khaled Sewify",
      "orcid": "0000-0002-0944-0518"
    },
    {
      "affs": [
        0
      ],
      "name": "Fahad Ali Faqihi"
    },
    {
      "affs": [
        0
      ],
      "name": "Rayan AlShayaa"
    },
    {
      "affs": [
        0
      ],
      "name": "Khaddash N. Issa"
    },
    {
      "affs": [
        0
      ],
      "name": "Saleh Almahwi"
    },
    {
      "affs": [
        0
      ],
      "name": "Jennifer Q. Gano",
      "orcid": "0000-0001-5198-268X"
    },
    {
      "affs": [
        0
      ],
      "name": "Adel Ali Alkenani"
    },
    {
      "affs": [
        2
      ],
      "name": "Ahmed Shaaban"
    },
    {
      "affs": [
        0
      ],
      "name": "Mohammad Al Odat"
    },
    {
      "affs": [
        0
      ],
      "name": "Abdullah Alquaydheb"
    },
    {
      "affs": [
        0
      ],
      "name": "Abdulrahman Alanazi"
    },
    {
      "affs": [
        0
      ],
      "name": "Basel Almuabbadi",
      "orcid": "0009-0003-0627-1987"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Muhammad Asim Rana"
    },
    {
      "affs": [
        0
      ],
      "name": "Basheer Abdelrahman"
    },
    {
      "affs": [
        0
      ],
      "name": "Huda Mhawish",
      "orcid": "0000-0002-1708-0970"
    },
    {
      "affs": [
        5
      ],
      "name": "Amr El-Husseini"
    },
    {
      "affs": [
        6
      ],
      "name": "Marcus Ewert Broman",
      "orcid": "0000-0002-1511-7346"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/35eyx05s4ndps.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15208028",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13706304/?tool=EBI",
  "id": "35eyx05s4ndps",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/20/8028",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Sepsis Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7222616804",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13706304/pdf/?tool=EBI",
  "pmcid": "PMC13706304",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/35eyx05s4ndps.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:00Z",
      "native_id": "10.3390/jcm15208028",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/20/8028"
    },
    {
      "first_seen": "2026-10-30T12:21:31Z",
      "native_id": "PMC:PMC13706304",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13706304"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Sepsis Diagnosis and Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "oXiris-Based Blood Purification Efficacy in Adults with Septic Shock and Acute Kidney Injury: The PURE Multicenter Pilot Randomized Clinical Trial",
  "title_text": "oXiris-Based Blood Purification Efficacy in Adults with Septic Shock and Acute Kidney Injury: The PURE Multicenter Pilot Randomized Clinical Trial",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:31Z",
  "url": "https://research.draconitic.com/paper/35eyx05s4ndps",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}