{
  "abstract": "Drug delivery precisely to the pulmonary vasculature represents a formidable challenge. Pediatric Acute Respiratory Distress Syndrome (PARDS) is an urgent public health concern accounting for high mortality and long-term morbidity due to severe damage to lung endothelial cells (ECs). Advanced target-specific therapeutic interventions to protect lung vasculature in PARDS are in dire need. FOXF1 protein is a critical mediator of lung angiogenesis and vascular repair after injury. However, whether FOXF1 is a useful pharmacological target for PARDS is unknown. Herein, we developed a universal nanoparticle-based Lung Endothelial Drug Delivery (LEDD) system to deliver hydrophobic small-molecule compounds specifically to lung ECs but not to other cells or organs. Based on single-cell RNA sequencing, FOXF1 expression was decreased in lung ECs in the mouse PARDS model. We used LEDD nanoparticles to restore FOXF1 by delivering a novel FOXF1-activating compound, TanFe[F], which prevents FOXF1 protein degradation. LEDD-TanFe[F] treatment increased FOXF1 protein and its activity in lung ECs in vitro and in vivo. LEDD-TanFe[F] treatment was non-toxic, well-tolerated, and improved mice survival in the PARDS model. LEDD-TanFe[F] reduced endothelial permeability, improved vascular repair, and alveolarization in injured neonatal lungs. LEDD-supported drug delivery precisely to lung ECs is a promising therapeutic approach in PARDS.",
  "abstract_shown": true,
  "affiliations": [
    "Phoenix Children's Research Institute, Department of Child Health, University of Arizona College of Medicine-Phoenix, Phoenix, USA.",
    "Division of Neonatology, Phoenix Children's Hospital, Phoenix, USA.",
    "Center for Cancer and Blood Diseases, Phoenix Children's Hospital, Phoenix, USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Afzaal N Mohammed",
      "orcid": "0000-0002-3488-0128"
    },
    {
      "affs": [
        0
      ],
      "name": "Zicheng Deng",
      "orcid": "0000-0001-6868-7927"
    },
    {
      "affs": [
        0
      ],
      "name": "Arnab Misra",
      "orcid": "0009-0009-5119-4777"
    },
    {
      "affs": [
        0
      ],
      "name": "Marcus Orzabal",
      "orcid": "0009-0000-6998-5942"
    },
    {
      "affs": [
        0
      ],
      "name": "Ananya Kondapally"
    },
    {
      "affs": [
        0
      ],
      "name": "Enhong Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Jonathan Do",
      "orcid": "0009-0003-5043-2936"
    },
    {
      "affs": [
        0
      ],
      "name": "Ying-Wei Lan"
    },
    {
      "affs": [
        0
      ],
      "name": "Fatemeh Kohram",
      "orcid": "0000-0001-6679-3478"
    },
    {
      "affs": [
        0
      ],
      "name": "Hunter Blackburn",
      "orcid": "0009-0000-1116-5247"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Andreas Damianos",
      "orcid": "0009-0005-4326-8749"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Tanya V Kalin",
      "orcid": "0000-0002-8545-8277"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Vladimir V Kalinichenko",
      "orcid": "0000-0003-3438-2660"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/35ks9ygwgj1k0.bib",
  "cited_by": 0,
  "doi": "10.1002/advs.78292",
  "fulltext_url": "https://europepmc.org/articles/PMC13669217",
  "id": "35ks9ygwgj1k0",
  "issns": [
    "2198-3844"
  ],
  "landing_url": "https://europepmc.org/article/MED/42875859",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
    ]
  ],
  "openalex": "W7222192777",
  "pdf_url": "https://europepmc.org/articles/PMC13669217?pdf=render",
  "pmcid": "PMC13669217",
  "pmid": "42875859",
  "published": "2026-10-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/35ks9ygwgj1k0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:46Z",
      "native_id": "MED:42875859",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42875859"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Development of Versatile Nanoparticle System for Efficient Drug Delivery into Pulmonary Endothelium.",
  "title_text": "Development of Versatile Nanoparticle System for Efficient Drug Delivery into Pulmonary Endothelium.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:46Z",
  "url": "https://research.draconitic.com/paper/35ks9ygwgj1k0",
  "venue": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
  "versions": []
}