{
  "abstract": "Fluorescence sensors are one of rapid technics for metal cation determination in cells, tissues and biological fluids. 8-Hydroxyquinoline (8HQ) derivatives have possess favorable photophysical and coordination properties for developing fluorescent metal sensors. 8HQ derivatives 2-(4-methoxystyryl)quinolin-8-ol (STQ-Me), 2-(4-ethoxyphenylethenyl)quinolin-8-ol (STQ-Et) and 2-(4-(trifluoromethyl)styryl) quinolin-8-ol (STQ-CF 3 ) were investigated. Absorbance and fluorescence spectra of 50 µM 8HQ derivatives in saline were evaluated in the presence of Mg 2+ , Ca 2+ , and Zn 2+ . The investigations were carried out on epidermal carcinoma of the mouth KB cell line. Among the studied compounds, STQ-Me demonstrates sufficient stability in saline and appears to be able to bind Zn 2+ with presumably some selectivity in the presence of Ca 2+ and Mg 2+ . The fluorescence intensity of STQ-Me solution increased with rising Zn 2+ concentration in the presence of Ca 2+ and Mg 2+ . Compounds STQ-Et and STQ-CF 3 demonstrated either weak divalent cation selectivity, poor stability and a pronounced tendency to aggregate in saline. In live KB cells incubated with ZnO NPs, STQ-Me produced a zinc-dependent fluorescence pattern similar to the reference probe TSQ. However, STQ-Me was likely unable to chelate protein-bound zinc, as evidenced by the dynamic fluorescence parameters of KB cells. Overall, STQ-Me demonstrates potential as a fluorescent probe for monitoring labile zinc in living cells, but further molecular optimization is required to enhance fluorescence output and improve binding to protein-associated zinc pools.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Pavlo Virych"
    },
    {
      "name": "Sergey Studzinsky"
    },
    {
      "name": "Petro Virych"
    },
    {
      "name": "Nataliya Kutsevol"
    },
    {
      "name": "Oksana Krupka"
    },
    {
      "name": "Vitalii Smokal"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/35rw4gexscff8.bib",
  "cited_by": 0,
  "doi": "10.1007/s42452-026-08817-5",
  "fulltext_url": null,
  "id": "35rw4gexscff8",
  "issns": [
    "3004-9261"
  ],
  "landing_url": "https://hal.science/hal-05796949v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "openalex",
      "1607|Molecular Sensors and Ion Detection"
    ]
  ],
  "openalex": "W7161140459",
  "pdf_url": "https://hal.science/hal-05796949/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-05-14",
  "publisher": "Springer",
  "ris": "https://research.draconitic.com/paper/35rw4gexscff8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:56Z",
      "native_id": "hal-05796949",
      "source": "hal",
      "url": "https://hal.science/hal-05796949v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1607|Molecular Sensors and Ion Detection",
      "subfield": "physical"
    }
  ],
  "title": "Quinoline derivatives as fluorescent probes for zinc determination in living cells",
  "title_text": "Quinoline derivatives as fluorescent probes for zinc determination in living cells",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:56Z",
  "url": "https://research.draconitic.com/paper/35rw4gexscff8",
  "venue": "Discover Applied Sciences",
  "versions": []
}