{
  "abstract": "Background and Objectives: Physical exercise is widely recognized as an effective non-pharmacological intervention that improves not only functional capacity but also cognition and quality of life in older adults. However, the molecular pathways through which it influences aging-related processes remain incompletely understood. This systematic review and meta-analysis aimed to synthesize current evidence on the effects of structured physical exercise intervention on molecular biomarkers associated with inflammation and oxidative stress in older adults.\n\nResearch Design and Methods: Randomized controlled trials that included participants ≥65 years old were identified through searches of PubMed, Scopus, Web of Science, Cumulative Index to Nursing and Allied Health Literature, and the Cochrane Library.\n\nResults: A total of 50 reports (4,379 participants) were included in the qualitative synthesis, and 38 of them in the different meta-analyses performed. Exercise interventions ranged from 8 weeks to 12 months and included aerobic, resistance, and multicomponent training. Pooled analyses indicated modest but significant reductions in C-Reactive Protein (CRP) and high-sensitivity CRP, as well as increases in Interleukin (IL)-10. Effects on other pro-inflammatory cytokines, including IL-6 and TNF-α, were inconsistent across studies. Evidence from a limited number of trials (n = 6) also suggested improvements in redox balance.\n\nDiscussion and Implications: Overall, structured physical exercise demonstrates a moderate immunomodulatory and antioxidant effect in older adults, although bias was moderate to high. PROSPERO registry: CRD420251006248.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Chenhui Chenhuichen",
      "orcid": "0000-0001-9232-7497"
    },
    {
      "name": "Yasmin Ezzatvar",
      "orcid": "0000-0002-9691-5998"
    },
    {
      "name": "Fabiola Zambom-Ferraresi",
      "orcid": "0000-0001-7068-5269"
    },
    {
      "name": "Carly Welch",
      "orcid": "0000-0003-3894-355X"
    },
    {
      "name": "Myriam Gorospe",
      "orcid": "0000-0001-5439-3434"
    },
    {
      "name": "Marta Montes",
      "orcid": "0000-0003-1223-8385"
    },
    {
      "name": "Marta Gutiérrez-Valencia",
      "orcid": "0000-0002-3229-6614"
    },
    {
      "name": "Juan José Lasarte",
      "orcid": "0000-0003-1641-3881"
    },
    {
      "name": "Thomas Jackson",
      "orcid": "0000-0001-6320-9600"
    },
    {
      "name": "Nicolás Martínez-Velilla",
      "orcid": "0000-0001-9576-9960"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3630aqwkf7mx8.bib",
  "cited_by": 0,
  "doi": "10.1093/geront/gnag228",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13730600/",
  "id": "3630aqwkf7mx8",
  "issns": [
    "0016-9013",
    "1758-5341"
  ],
  "landing_url": "https://doi.org/10.1093/geront/gnag228",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "AcademicSubjects/SOC02600"
    ],
    [
      "heading",
      "Review Article"
    ],
    [
      "openalex",
      "2737|Exercise and Physiological Responses"
    ]
  ],
  "openalex": "W7214379995",
  "pdf_url": "https://academic.oup.com/gerontologist/advance-article-pdf/doi/10.1093/geront/gnag228/71384345/gnag228.pdf",
  "pmcid": "PMC13730600",
  "pmid": "42786581",
  "published": "2026-09-24",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/3630aqwkf7mx8.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:23:07Z",
      "native_id": "PMC13730600",
      "source": "pmc",
      "url": "https://doi.org/10.1093/geront/gnag228"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Exercise and Physiological Responses",
      "subfield": "physiology"
    }
  ],
  "title": "Impact of supervised physical exercise on inflammatory and oxidative stress biomarkers in older adults: a systematic review and meta-analysis of randomized controlled trials",
  "title_text": "Impact of supervised physical exercise on inflammatory and oxidative stress biomarkers in older adults: a systematic review and meta-analysis of randomized controlled trials",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:23:07Z",
  "url": "https://research.draconitic.com/paper/3630aqwkf7mx8",
  "venue": "The Gerontologist",
  "versions": []
}