{
  "abstract": "Patients with newly diagnosed acute leukemia are at increased risk of bleeding during vascular access because of thrombocytopenia and coagulopathy. The primary objective of this single-center retrospective study (November 2023–August 2024; Ruijin Hospital) was to evaluate the feasibility and safety of a peripherally inserted central catheter (PICC) puncture and nursing protocol incorporating ultrasound-guided Seldinger puncture, controlled sheath withdrawal with gauze-assisted compression, and localized hemostatic dressing in 101 patients prior to chemotherapy. The first-attempt success rate was 95.1%. At 24 h, active oozing occurred in 14 patients (13.9%); all events were CTCAE grade 1–2 and were controlled with local measures. Platelet count (PLT; OR = 0.972, P = 0.029) and fibrinogen (Fg; OR = 0.594, P = 0.049) were independent predictors of bleeding. On ROC analysis, PLT showed greater predictive value (AUC = 0.762, 95% CI 0.628–0.880). Catheter malposition and thrombosis each occurred in 1.0% of patients (CTCAE grade 2 and grade 1, respectively); no phlebitis, catheter-related infection, or grade ≥ 3 adverse events were reported. The technique was safe and feasible, and PLT and Fg helped predict bleeding risk. Prospective multicenter validation is warranted.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00277-026-07241-4.",
  "abstract_shown": true,
  "affiliations": [
    "Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025 China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yulei Wei"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaohong Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Fei Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yang He"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinlian Hu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/365wvxswzy34d.bib",
  "cited_by": 0,
  "doi": "10.1007/s00277-026-07241-4",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13748009/",
  "id": "365wvxswzy34d",
  "issns": [
    "0939-5555",
    "1432-0584"
  ],
  "landing_url": "https://doi.org/10.1007/s00277-026-07241-4",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2706|Central Venous Catheters and Hemodialysis"
    ]
  ],
  "openalex": "W7202259510",
  "pdf_url": null,
  "pmcid": "PMC13748009",
  "pmid": "43002293",
  "published": "2026-08-12",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/365wvxswzy34d.ris",
  "sources": [
    {
      "first_seen": "2026-11-13T12:25:35Z",
      "native_id": "PMC13748009",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s00277-026-07241-4"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2706|Central Venous Catheters and Hemodialysis",
      "subfield": "general"
    }
  ],
  "title": "Safety and feasibility of peripherally inserted central catheter (PICC) placement in patients with newly diagnosed acute leukemia: A single-center retrospective study",
  "title_text": "Safety and feasibility of peripherally inserted central catheter (PICC) placement in patients with newly diagnosed acute leukemia: A single-center retrospective study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T12:25:35Z",
  "url": "https://research.draconitic.com/paper/365wvxswzy34d",
  "venue": "Annals of Hematology",
  "versions": []
}