{
  "abstract": "Alterations in sphingolipids (SLs), oxylipins (OLs) and cytokines (CKs) are central to neuroinflammation. However, the effects of low doses Fumonisins B (FBs) on these analytes in the avian brain remain unclear.This study investigated SLs, OLs, CKs, and the activities of phospholipase A2c (PLA2c) and cyclooxygenase 2 (COX2) in the brains of chickens exposed to FB at a nominally safe dose of 14.6 mg FB1 + FB2/kg for 14 and 21 days. Targeted LC-MS/MS analyses revealed that FB exposure increased brain concentrations of sphingosine, N-acetyl-sphingosine, sphingosine 1-phosphate (So1P), ceramides (Cers), and sphingomyelins (SM). The Cer:SM ratio was elevated at 14 days but normalized by 21 days, whereas the So1P:Cer ratio rose at 14 days and continued to increase at 21 days. These changes coincided with elevated PLA2c and COX2 activities. OL profiling indicated a modest rise in pro-inflammatory arachidonic acid-derived COX metabolites at 14 days, while anti-inflammatory OLs derived from COX and lipoxygenase (LOX) pathways, including PGE2, 15-HETE, and 17-HDHA, increased significantly at 21 days. In contrast, the levels of CKs changed only slightly. Brain concentrations of Fumonisin B1 (FB1) indicated increased blood–brain barrier permeability.These findings highlight a key role of Cers in modulating OL production in FB neurotoxicity.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Philippe Guerre"
    },
    {
      "name": "Elodie Lassallette"
    },
    {
      "name": "Didier Tardieu"
    },
    {
      "name": "Marie Berthommier"
    },
    {
      "name": "Alix Pierron Baysse"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3664cx50svp68.bib",
  "cited_by": 1,
  "doi": "10.3390/antiox15050546",
  "fulltext_url": null,
  "id": "3664cx50svp68",
  "issns": [
    "2076-3921",
    "2076-3921"
  ],
  "landing_url": "https://hal.inrae.fr/hal-05752240v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.ba"
    ],
    [
      "openalex",
      "1312|Sphingolipid Metabolism and Signaling"
    ]
  ],
  "openalex": "W7159863892",
  "pdf_url": "https://hal.inrae.fr/hal-05752240/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-16",
  "publisher": "MDPI",
  "ris": "https://research.draconitic.com/paper/3664cx50svp68.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:35Z",
      "native_id": "hal-05752240",
      "source": "hal",
      "url": "https://hal.inrae.fr/hal-05752240v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.ba",
      "subfield": "zoology-behaviour"
    }
  ],
  "title": "A Nominally Safe Dose of Fumonisins Induces Mild Neuroinflammation in Chickens by Targeting Sphingolipids and Oxylipins but Not Cytokines",
  "title_text": "A Nominally Safe Dose of Fumonisins Induces Mild Neuroinflammation in Chickens by Targeting Sphingolipids and Oxylipins but Not Cytokines",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:35Z",
  "url": "https://research.draconitic.com/paper/3664cx50svp68",
  "venue": "Antioxidants",
  "versions": []
}