{
  "abstract": "Cytos Multimodal Pooled Screening (Cytos MPS) measures CRISPR guide identity, morphology, native 3' transcriptome, and protein abundance and localization in the same fixed cells. Following IL-1{beta} stimulation, cells with higher nuclear NF-{kappa}B show lower phospho-p38/HSP27 and higher NFKBIA/DUSP1 in the same cell, a measurement neither imaging nor transcriptomics alone provides. TGFBR2 and CTNNB1 perturbations produce distinct multimodal phenotypes. Guide representation and perturbation transcriptional responses agree with an orthogonal single-cell transcriptomic platform.",
  "abstract_shown": true,
  "affiliations": [
    "Element Biosciences, San Diego, CA, USA"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "T. Lopez"
    },
    {
      "name": "J. Rabalais"
    },
    {
      "name": "B. Song"
    },
    {
      "name": "A. Boddicker"
    },
    {
      "name": "A. Schwartz"
    },
    {
      "name": "D. Honigfort"
    },
    {
      "name": "J. Zhao"
    },
    {
      "name": "M. Kellinger"
    },
    {
      "affs": [
        0
      ],
      "name": "S. Kruglyak"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/36y164zn40y56.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.20.752925",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.20.752925v1.full",
  "id": "36y164zn40y56",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.20.752925v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "cell biology"
    ],
    [
      "openalex",
      "1312|CRISPR and Genetic Engineering"
    ]
  ],
  "openalex": "W7214181899",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.20.752925v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-20",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/36y164zn40y56.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:24:26Z",
      "native_id": "10.64898/2026.09.20.752925",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.20.752925v2"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:cell biology",
      "subfield": "cell-biology"
    }
  ],
  "title": "CytosMPS: an automated multimodal pooled screening platform for protein, morphology and transcriptomics",
  "title_text": "CytosMPS: an automated multimodal pooled screening platform for protein, morphology and transcriptomics",
  "type": "preprint",
  "updated_at": "2026-10-30T12:26:59Z",
  "url": "https://research.draconitic.com/paper/36y164zn40y56",
  "venue": "bioRxiv",
  "versions": []
}