{
  "abstract": "ackground: In wild-type transthyretin cardiac amyloidosis (ATTRwt-CM), the prognostic role of carpal tunnel syndrome (CTS) is unclear and that of lumbar spinal stenosis (SS) remains unexplored. Objectives: The aim was to examine the diagnostic, therapeutic, and prognostic relevance of bilateral CTS and SS in ATTRwt-CM, in relation to the tafamidis treatment. Methods: Clinical characteristics of 1,449 patients with ATTRwt-CM were evaluated in a multicenter cohort. The primary endpoint was all-cause mortality. Cox multivariable regression was used to assess mortality in patients with and without CTS and SS. Results: Preceding an ATTRwt-CM diagnosis, CTS and SS were present in 29% and 22% of patients, respectively, without sex-difference. CTS (P < 0.001), but not SS, was more prevalent among younger patients. Tenosynovial red flags and ATTRwt-CM diagnosis occurred approximately 4 years later in females vs males, with similar preceding time, suggesting later female ATTRwt-CM disease onset. Patients with vs without CTS and SS had lower National Amyloidosis Centre disease stage (P ≤ 0.001), despite similar symptomatic status. During a mean follow-up of 2.3 ± 1.8 years, 73% (1,052/1,449) of patients were initiated on tafamidis and 28% (406) died. Tafamidis was initiated more in CTS positive vs negative patients (78% vs 71%; P = 0.008), on average 2.3 years earlier (P < 0.001). More SS positive than negative patients received tafamidis (78% vs 71%; P = 0.018), but at similar age (P = 0.394). CTS (HR: 0.70; 95% CI: 0.52-0.95) and SS (HR: 0.68; 95% CI: 0.48-0.97) predicted lower mortality. Conclusions: Both CTS and SS not only enable early ATTRwt-CM diagnosis and treatment initiation, but independently relate to improved survival, potentiating a role for opportunistic screening.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 30,
  "authors": [
    {
      "name": "Philippe Debonnaire"
    },
    {
      "name": "Karl Dujardin"
    },
    {
      "name": "Erwan Donal"
    },
    {
      "name": "Nicolas Verheyen"
    },
    {
      "name": "Matthias Dupont"
    },
    {
      "name": "Delphine Vervloet"
    },
    {
      "name": "Philippe Timmermans"
    },
    {
      "name": "Anne-Catherine Pouleur"
    },
    {
      "name": "Steven Droogmans"
    },
    {
      "name": "Victor Sarli Issa"
    },
    {
      "name": "Raluca Dulgheru"
    },
    {
      "name": "Ruxandra Jurcut"
    },
    {
      "name": "Madelien Regeer"
    },
    {
      "name": "Antoine Bondue"
    },
    {
      "name": "Emma Christiaen"
    },
    {
      "name": "Wouter l'Hoyes"
    },
    {
      "name": "Nicolas Wyseure"
    },
    {
      "name": "Mélanie Bézard"
    },
    {
      "name": "David Zach"
    },
    {
      "name": "Nora Schwegel"
    },
    {
      "name": "Robbe Knapen"
    },
    {
      "name": "Lars Buytaert"
    },
    {
      "name": "Nils de Marneffe"
    },
    {
      "name": "Robert Adam"
    },
    {
      "name": "Nina Ajmone Marsan"
    },
    {
      "name": "Francis Bonte"
    },
    {
      "name": "Nikolaas Vantomme"
    },
    {
      "name": "Ian Buysschaert"
    },
    {
      "name": "Rene Tavernier"
    },
    {
      "name": "Sander Trenson"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/37ak36gp0gf4v.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jacadv.2026.102631",
  "fulltext_url": null,
  "id": "37ak36gp0gf4v",
  "issns": [
    "2772-963X"
  ],
  "landing_url": "https://hal.science/hal-05830116v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.ib"
    ],
    [
      "openalex",
      "1312|Amyloidosis: Diagnosis, Treatment, Outcomes"
    ]
  ],
  "openalex": "W7140299806",
  "pdf_url": "https://hal.science/hal-05830116/document",
  "pmcid": null,
  "pmid": "41906617",
  "published": "2026-10-21",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/37ak36gp0gf4v.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:00Z",
      "native_id": "hal-05830116",
      "source": "hal",
      "url": "https://hal.science/hal-05830116v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.ib",
      "subfield": "systems-synthetic"
    }
  ],
  "title": "Diagnostic, Therapeutic, and Prognostic Implications of Carpal Tunnel Syndrome and Spinal Stenosis in Wild-type ATTR-Cardiomyopathy",
  "title_text": "Diagnostic, Therapeutic, and Prognostic Implications of Carpal Tunnel Syndrome and Spinal Stenosis in Wild-type ATTR-Cardiomyopathy",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:00Z",
  "url": "https://research.draconitic.com/paper/37ak36gp0gf4v",
  "venue": "JACC. Advances",
  "versions": []
}