{
  "abstract": "Background: The triglyceride-glucose body roundness index (TyG-BRI) has emerged as a promising biomarker correlated with elevated risks of adverse cardiovascular events. Notably, the potential linkage between TyG-BRI and carotid atherosclerosis (CAS) has not been formally evaluated in individuals with type 2 diabetes mellitus.\n\nMethods: This cross-sectional observational study consecutively enrolled 1060 adults with type 2 diabetes mellitus in Fujian, China. Anthropometric measurements and fasting venous blood biochemical data were collected to calculate TyG-BRI. CAS was ascertained using high-resolution B-mode ultrasound. Spearman correlation analysis was performed to examine the correlations between TyG-BRI and metabolic indicators. Following stepwise adjustment for confounding variables, hierarchical binary logistic regression and restricted cubic spline curves were applied to evaluate the association of TyG-BRI with CAS risk as well as potential effect modifiers. Finally, receiver operating characteristic (ROC) curve analysis was conducted to evaluate the identification capability of TyG-BRI for CAS.\n\nResults: Patients with CAS had significantly higher TyG-BRI levels than non-CAS controls. TyG-BRI was positively correlated with carotid intima-media thickness, glycated hemoglobin (HbA1c), blood pressure, total cholesterol, low-density lipoprotein cholesterol, and uric acid. In fully adjusted models, elevated TyG-BRI was non-linearly associated with higher CAS risk (P for overall association < 0.001, P for non-linearity < 0.01). Per 1-standard-deviation increment in TyG-BRI, the ORs were 1.503 (95% CI 1.281–1.763, P < 0.001) for carotid intima-media thickening, 1.453 (95% CI 1.236–1.709, P < 0.001) for carotid plaque, and 2.247 (95% CI 1.820–2.773, P < 0.001) for CAS. Associations remained consistent across subgroups stratified by age, sex, body mass index (BMI), HbA1c and hypertension, with a stronger effect in participants with BMI < 24 kg/m² (OR 4.838, 95% CI 3.007–7.784, P < 0.001). ROC analysis showed TyG-BRI significantly identified CAS (AUC = 0.698, 95% CI 0.664–0.731, P < 0.001), outperforming TyG and TyG-BMI while matching the performance of the composite indices of TyG combined with waist circumference or waist-to-height ratio.\n\nConclusion: TyG-BRI demonstrated an independent, non-linear dose-response association with CAS risk in type 2 diabetes. Its integration into cardiovascular risk stratification holds promise for enabling earlier identification of CAS.",
  "abstract_shown": true,
  "affiliations": [
    "Longyan First Affiliated Hospital of Fujian Medical University , , ,",
    "State Grid Longyan Electric Power Supply Company , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Cuihua Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yan Tong"
    },
    {
      "affs": [
        1
      ],
      "name": "Yan Luo"
    },
    {
      "affs": [
        0
      ],
      "name": "Chengwen Xie"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/37bfw0qywzmw8.bib",
  "cited_by": 0,
  "doi": "10.3389/fendo.2026.1952432",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13668577/?tool=EBI",
  "id": "37bfw0qywzmw8",
  "issns": [
    "1664-2392"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13668577",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2712|Diabetes, Cardiovascular Risks, and Lipoproteins"
    ]
  ],
  "openalex": "W7215067055",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13668577/pdf/?tool=EBI",
  "pmcid": "PMC13668577",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/37bfw0qywzmw8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:18Z",
      "native_id": "PMC:PMC13668577",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13668577"
    },
    {
      "first_seen": "2026-10-30T12:20:20Z",
      "native_id": "10.3389/fendo.2026.1952432",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1952432/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2712|Diabetes, Cardiovascular Risks, and Lipoproteins",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "The association of triglyceride-glucose body roundness index with carotid atherosclerosis in type 2 diabetes: a cross-sectional study",
  "title_text": "The association of triglyceride-glucose body roundness index with carotid atherosclerosis in type 2 diabetes: a cross-sectional study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:20Z",
  "url": "https://research.draconitic.com/paper/37bfw0qywzmw8",
  "venue": "Frontiers in endocrinology",
  "versions": []
}