{
  "abstract": "Introduction\n\nChronic diseases disproportionately affect people facing social and economic adversity. Community health workers (CHWs) are increasingly recognized as a key workforce for addressing social determinants of health (SDOH). However, evidence for the effect of CHW-led interventions on social and clinical outcomes among US adults with chronic disease is limited. This systematic review evaluated the effects of CHW-led interventions on SDOH and health outcomes.Methods\n\nFollowing PRISMA guidelines and a registered Prospero protocol, we searched PubMed, Scopus, and Embase (Ovid) in April 2024 for US-based randomized or quasi-experimental studies involving adults with chronic disease and a patient-facing CHW intervention addressing at least 1 SDOH domain. Eligible studies were required to have a comparator group and report social or health outcomes. We used standardized forms to extract data and assess quality.Results\n\nWe identified 1,939 records and screened 1,058 abstracts. We reviewed 110 full-text articles; 7 studies met inclusion criteria. All were randomized controlled trials addressing at least 1 SDOH domain. Interventions most commonly targeted health care access, housing stability, or care coordination among adults with diabetes, HIV, asthma, hepatitis C, or hearing loss. CHW interventions demonstrated improvements in several condition-specific clinical outcomes, but overall effects on major clinical indicators were modest and inconsistent.Conclusion\n\nCHW-led interventions show promise for addressing social needs and improving engagement in care among adults with chronic disease, but evidence of meaningful clinical benefit is still limited. The lack of large, well-powered trials underscores the need for more rigorous research to strengthen the evidence base for CHW-driven SDOH interventions in US health systems.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.",
    "Institute for Health Equity Research, Icahn School of Medicine at Mount Sinai, New York, New York.",
    "Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.",
    "Howard University College of Medicine, Washington, District of Columbia.",
    "Levy Library, Icahn School of Medicine at Mount Sinai, New York, New York.",
    "Center for Nursing Research and Innovation, Mount Sinai Health System, New York, New York."
  ],
  "article_type": "systematic review",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Marcee Wilder"
    },
    {
      "affs": [
        0
      ],
      "name": "Aleksandra Degtyar"
    },
    {
      "affs": [
        3
      ],
      "name": "Jasmine McKay"
    },
    {
      "affs": [
        0
      ],
      "name": "Shruti Mavuri"
    },
    {
      "affs": [
        4
      ],
      "name": "Mia Bolton"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Lynne D Richardson"
    },
    {
      "affs": [
        0,
        1,
        5
      ],
      "name": "Kimberly Souffront"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/37cjqbj1898xg.bib",
  "cited_by": 0,
  "doi": "10.5888/pcd23.260132",
  "fulltext_url": "https://europepmc.org/articles/PMC13721287",
  "id": "37cjqbj1898xg",
  "issns": [
    "1545-1151"
  ],
  "landing_url": "https://europepmc.org/article/MED/42955714",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Systematic Review"
    ],
    [
      "openalex",
      "3600|Community Health and Development"
    ]
  ],
  "openalex": "W7224111942",
  "pdf_url": "https://europepmc.org/articles/PMC13721287?pdf=render",
  "pmcid": "PMC13721287",
  "pmid": "42955714",
  "published": "2026-10-29",
  "publisher": "Centers for Disease Control and Prevention",
  "ris": "https://research.draconitic.com/paper/37cjqbj1898xg.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:21Z",
      "native_id": "MED:42955714",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42955714"
    },
    {
      "first_seen": "2026-11-03T12:22:00Z",
      "native_id": "PMC13721287",
      "source": "pmc",
      "url": "https://doi.org/10.5888/pcd23.260132"
    }
  ],
  "subjects": [],
  "title": "Community Health Worker Interventions Addressing Social Determinants of Health in Chronic Disease: A Systematic Review.",
  "title_text": "Community Health Worker Interventions Addressing Social Determinants of Health in Chronic Disease: A Systematic Review.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:00Z",
  "url": "https://research.draconitic.com/paper/37cjqbj1898xg",
  "venue": "Preventing chronic disease",
  "versions": []
}