{
  "abstract": "An efficient and environmentally benign Al₂O₃ nanoparticle-catalyzed protocol was developed for the synthesis of nicotinonitrile derivatives under mild reaction conditions using an ethanol-water solvent system. The Al₂O₃ nanoparticles were synthesized via a green approach employing Coccinia indica leaf extract and characterized by XRD, SEM, EDS, FTIR, and BET analyses. The developed catalytic protocol afforded excellent yields (88-96%) within short reaction times (18-40 min), demonstrating a broad substrate scope, high catalytic activity, and excellent recyclability. The synthesized nicotinonitrile derivatives were further evaluated for their antimicrobial activity against S. aureus, B. subtilis, P. aeruginosa, and E. coli, exhibiting promising antibacterial efficacy. Molecular docking studies against the bacterial DNA gyrase B enzyme further supported their potential antimicrobial mechanism, while in silico ADMET analysis indicated favorable drug-likeness and toxicity profiles. Overall, this study demonstrates a sustainable nanocatalytic strategy for the efficient synthesis of biologically active nicotinonitrile derivatives.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, Yashavantrao Chavan Institute of Science, Constituent College of Karmaveer Bhaurao Patil University Satara-415001 Maharashtra India prakashkokare004@gmail.com moreashwini0506@gmail.com panditnilesh40@gmail.com vishughanwat@yahoo.in aniketsawant269@gmail.com sunandamahanwar@gmail.com.",
    "Department of Chemistry, Shivaji University Kolhapur 416004 Maharashtra India chaitali12jan@gmail.com.",
    "Department of Microbiology, Yashavantrao Chavan Institute of Science, Constituent College of Karmaveer Bhaurao Patil University Satara-415001 Maharashtra India amolsjadhav12@gmail.com.",
    "Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to Be University) Karad Maharashtra 415539 India dipakpmali19@gmail.com.",
    "Department of Chemistry, Sadguru Gadage Maharaj College Karad 415124 Maharashtra India santosh.san143@gmail.com.",
    "Karmaveer Bhaurao Patil University Satara-415001 Maharashtra India.",
    "Department of Chemistry, Georgetown University Washington DC USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Prakash Kokare"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ashwini More"
    },
    {
      "affs": [
        0
      ],
      "name": "Nilesh Pandit"
    },
    {
      "affs": [
        0
      ],
      "name": "Vishvanath Ghanwat"
    },
    {
      "affs": [
        2
      ],
      "name": "Amol Jadhav"
    },
    {
      "affs": [
        0
      ],
      "name": "Aniket Sawant"
    },
    {
      "affs": [
        1
      ],
      "name": "Chaitali Bagade"
    },
    {
      "affs": [
        3
      ],
      "name": "Dipak Mali",
      "orcid": "0000-0001-6916-2946"
    },
    {
      "affs": [
        0
      ],
      "name": "Sunanda Mahanwar"
    },
    {
      "affs": [
        4,
        5,
        6
      ],
      "name": "Santosh Kamble",
      "orcid": "0000-0002-4668-1628"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/37vfmhwb22c1e.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra06809j",
  "fulltext_url": "https://europepmc.org/articles/PMC13679712",
  "id": "37vfmhwb22c1e",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898952",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1605|Multicomponent Synthesis of Heterocycles"
    ]
  ],
  "openalex": "W7222940861",
  "pdf_url": "https://europepmc.org/articles/PMC13679712?pdf=render",
  "pmcid": "PMC13679712",
  "pmid": "42898952",
  "published": "2026-10-19",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/37vfmhwb22c1e.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42898952",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898952"
    },
    {
      "first_seen": "2026-11-07T12:23:35Z",
      "native_id": "PMC13679712",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra06809j"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Multicomponent Synthesis of Heterocycles",
      "subfield": "organic"
    }
  ],
  "title": "Biofabricated Al₂O₃ nanoparticles as a recyclable heterogeneous catalyst for nicotinonitrile synthesis: antimicrobial activity, molecular docking and ADMET assessment.",
  "title_text": "Biofabricated Al₂O₃ nanoparticles as a recyclable heterogeneous catalyst for nicotinonitrile synthesis: antimicrobial activity, molecular docking and ADMET assessment.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:23:35Z",
  "url": "https://research.draconitic.com/paper/37vfmhwb22c1e",
  "venue": "RSC advances",
  "versions": []
}