{
  "abstract": "Cryo-electron tomography (cryo-ET) provides a unique window into molecular organization in cellular environments (in situ). However, the interpretation of molecular structural information is complicated by several intrinsic properties of cryo-ET data, such as noise, missing wedge, and continuous conformational variability of the molecules. These challenges shift the emphasis from high-resolution structure determination toward validation and interpretation of low-resolution density maps and analysis of conformational flexibility. Molecular dynamics (MD) simulations are particularly well suited to this task, as they provide a physically grounded way to explore continuous conformational transitions consistent with both experimental data and molecular energetics. This review focuses on the roles of MD simulations in cryo-ET, emphasizing their use in emerging methods for conformational landscape determination.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "name": "Slavica Jonic"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/380bmptkxcj2s.bib",
  "cited_by": 0,
  "doi": "10.1016/j.sbi.2026.103386",
  "fulltext_url": null,
  "id": "380bmptkxcj2s",
  "issns": [
    "0959-440X"
  ],
  "landing_url": "https://hal.science/hal-05696382v2",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.info"
    ],
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.info.info-bi"
    ],
    [
      "openalex",
      "1315|Advanced Electron Microscopy Techniques and Applications"
    ]
  ],
  "openalex": "W7212188163",
  "pdf_url": "https://hal.science/hal-05696382/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-10",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/380bmptkxcj2s.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:45Z",
      "native_id": "hal-05696382",
      "source": "hal",
      "url": "https://hal.science/hal-05696382v2"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1315|Advanced Electron Microscopy Techniques and Applications",
      "subfield": "structural-biology"
    }
  ],
  "title": "Conformational landscapes in cryo-electron tomography data based on molecular dynamics simulations",
  "title_text": "Conformational landscapes in cryo-electron tomography data based on molecular dynamics simulations",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:45Z",
  "url": "https://research.draconitic.com/paper/380bmptkxcj2s",
  "venue": "Current Opinion in Structural Biology",
  "versions": []
}