{
  "abstract": "INTRODUCTION: We examined whether stroke induces chronic cerebrovascular dysfunction and thereby exacerbates A{beta} pathology. METHODS: We exposed Tg2576 mice to a transient mild subcortical ischemia and examined cerebrovascular function at chronic timepoints as well as reactive astrocytes and A{beta} deposition post-mortem. RESULTS: Baseline cerebral blood flow and cerebrovascular reactivity (CVR) are both influenced by anesthesia regimen. A{beta} strongly impairs CVR at earlier ages, while mild ischemia impairs CVR at later ages. Mild ischemia reduces neurovascular coupling more strongly than A{beta} and synergistically increases A{beta} deposition in Tg2576 mice. DISCUSSION: Stroke-induced cerebrovascular dysfunction and astrocyte reactivity persist for long periods after the injury. Although there is variability in the spatiotemporal progression of ischemia- and A{beta}-induced vascular impairments, they generally follow the pattern of Thal staging. Surprisingly, the ischemia+A{beta} group showed the least cerebrovascular dysfunction yet an exacerbation of A{beta} deposition, suggesting that these pathologies are connected but not tightly coupled.",
  "abstract_shown": true,
  "affiliations": [
    "Oregon Health & Science University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "O. Ismail"
    },
    {
      "name": "S. S. Woodruff"
    },
    {
      "name": "B. Zimmerman"
    },
    {
      "name": "W. Zhang"
    },
    {
      "name": "T. L. Stackhouse"
    },
    {
      "name": "M. M. Pike"
    },
    {
      "name": "R. L. Woltjer"
    },
    {
      "affs": [
        0
      ],
      "name": "A. Mishra"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/38bgznzgr53qr.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.08.29.746901",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.08.29.746901v1.full",
  "id": "38bgznzgr53qr",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.08.29.746901v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2737|Alzheimer's disease research and treatments"
    ]
  ],
  "openalex": "W7207842262",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.08.29.746901v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/38bgznzgr53qr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:07Z",
      "native_id": "10.64898/2026.08.29.746901",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.08.29.746901v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Stroke and Alzheimer's disease have distinct consequences on neurovascular function but synergize to increase amyloid deposition",
  "title_text": "Stroke and Alzheimer's disease have distinct consequences on neurovascular function but synergize to increase amyloid deposition",
  "type": "preprint",
  "updated_at": "2026-10-30T12:19:07Z",
  "url": "https://research.draconitic.com/paper/38bgznzgr53qr",
  "venue": "bioRxiv",
  "versions": []
}