{
  "abstract": "BACKGROUND: Adequate endothelization after drug-eluting stent (DES) implantation is essential to reduce thrombotic risk. Adequate strut coverage (ASC) is defined as ≥40 μm on optical coherence tomography, but its functional significance remains uncertain. Coronary angioscopy can assess neointimal function by detecting thrombus and plaque color. This study evaluated functionally adequate endothelization and contributing factors after DES implantation. METHODS AND RESULTS: Post hoc analyses of the COLLABORATION 1 and 2 studies were performed using serial optical coherence tomography and coronary angioscopy 1 and 12 months after DES implantation. Four DES types were examined: durable polymer everolimus-eluting stent (DP-EES); sirolimus-eluting stent (SES); polymer-free biolimus-coated stent (PF-BCS); and dual-therapy sirolimus-eluting stent (DTS). PF-BCS and DTS were classified as \"ingenious\" DES, and DP-EES and SES were classified as \"fundamental.\" The correlation between the percentage of struts with ≥40 μm coverage (%ASC) and functional neointima (i.e., no thrombus and white plaque) was assessed. Among 150 patients (177 lesions), thrombus and yellow plaque were inversely correlated with %ASC at 12 months. Cut-off values of %ASC were 67% for thrombus prevention and 90% for plaque stabilization. Multivariable analysis identified the use of ingenious DES, prasugrel therapy, and hypertension as independent predictors of chronic adequate endothelization. CONCLUSIONS: Functional protection against thrombus requires %ASC ≥67%, and plaque stabilization requires ≥90%. The use of ingenious DESs and prasugrel contributes to improved chronic adequate endothelization.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 21,
  "authors": [
    {
      "name": "Masami Nishino"
    },
    {
      "name": "Yasuyuki Egami"
    },
    {
      "name": "Hiroaki Nohara"
    },
    {
      "name": "Shodai Kawanami"
    },
    {
      "name": "Koji Yasumoto"
    },
    {
      "name": "Naotaka Okamoto"
    },
    {
      "name": "Yasuharu Matsunaga-Lee"
    },
    {
      "name": "Masamichi Yano"
    },
    {
      "name": "Tatsuya Shiraki"
    },
    {
      "name": "Daisuke Nakamura"
    },
    {
      "name": "Isamu Mizote"
    },
    {
      "name": "Takayuki Ishihara"
    },
    {
      "name": "Toshiaki Mano"
    },
    {
      "name": "Takahisa Yamada"
    },
    {
      "name": "Naoki Itaya"
    },
    {
      "name": "Takaharu Nakayoshi"
    },
    {
      "name": "Takafumi Ueno"
    },
    {
      "name": "Daisaku Nakatani"
    },
    {
      "name": "Shungo Hikoso"
    },
    {
      "name": "Shinsuke Nanto"
    },
    {
      "name": "Yasushi Sakata"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/38d575hgwfpz5.bib",
  "cited_by": 0,
  "doi": "10.1253/circj.cj-25-1123",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/circj/90/8/90_CJ-25-1123/_article",
  "id": "38d575hgwfpz5",
  "issns": [
    "1347-4820",
    "1346-9843"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/circj/90/8/90_CJ-25-1123/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/cardiovascular"
    ],
    [
      "openalex",
      "2746|Coronary Interventions and Diagnostics"
    ]
  ],
  "openalex": "W7140084522",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-24",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/38d575hgwfpz5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.1253/circj.cj-25-1123",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/circj/90/8/90_CJ-25-1123/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Coronary Interventions and Diagnostics",
      "subfield": "surgery"
    }
  ],
  "title": "Assessment of and Factors Contributing to Adequate Endothelization After Drug-Eluting Stent Implantation",
  "title_text": "Assessment of and Factors Contributing to Adequate Endothelization After Drug-Eluting Stent Implantation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/38d575hgwfpz5",
  "venue": "Circulation Journal",
  "versions": []
}