{
  "abstract": "AIMS: ADAMTS18 is a secreted metalloproteinase implicated in vascular homeostasis and protection against ischemic brain injury. However, its clinical relevance in acute ischemic stroke (AIS) remains unclear. METHODS: We retrospectively analyzed 194 AIS patients from the Chengdu Stroke Registry. Serum ADAMTS18 levels were measured within 48 hours of admission using ELISA. Associations between ADAMTS18 levels and 3-month poor outcomes (modified Rankin Scale score 3-6) were evaluated using logistic regression. Predictive performance was assessed using area under the receiver operating characteristic curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI). RESULTS: ＜0.001). Incorporating ADAMTS18 into predictive models improved discrimination (AUC = 0.91 vs. 0.86, P = 0.011), IDI (11.14%, P＜0.001), and NRI (77.1%, P＜0.001). CONCLUSION: Lower admission ADAMTS18 levels are independently associated with poor 3-month functional outcomes after AIS and may provide additional prognostic information.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Ting Cui"
    },
    {
      "name": "Huan Wang"
    },
    {
      "name": "Yuyi Zhu"
    },
    {
      "name": "Mingxi Chen"
    },
    {
      "name": "Yaqi Chen"
    },
    {
      "name": "Keying Wu"
    },
    {
      "name": "Junfeng Liu"
    },
    {
      "name": "Zilong Hao"
    },
    {
      "name": "Bo Wu"
    },
    {
      "name": "Deren Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/38za386dy0v12.bib",
  "cited_by": 0,
  "doi": "10.5551/jat.66202",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/jat/33/10/33_66202/_article",
  "id": "38za386dy0v12",
  "issns": [
    "1880-3873",
    "1340-3478"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/jat/33/10/33_66202/_article",
  "language": null,
  "licence": "CC-BY-NC-SA",
  "licence_label": "CC BY-NC-SA",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/cardiovascular"
    ],
    [
      "openalex",
      "2713|Acute Ischemic Stroke Management"
    ]
  ],
  "openalex": "W7164212934",
  "pdf_url": "https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_66202/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/38za386dy0v12.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:22Z",
      "native_id": "10.5551/jat.66202",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/jat/33/10/33_66202/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Acute Ischemic Stroke Management",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Serum ADAMTS18 Levels at Admission Are Associated With 3-Month Functional Outcome After Acute Ischemic Stroke",
  "title_text": "Serum ADAMTS18 Levels at Admission Are Associated With 3-Month Functional Outcome After Acute Ischemic Stroke",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:22Z",
  "url": "https://research.draconitic.com/paper/38za386dy0v12",
  "venue": "Journal of Atherosclerosis and Thrombosis",
  "versions": []
}