{
  "abstract": "Coordination of mitochondrial functional states with nuclear transcriptional programs remain critical for cellular adaptation. Here, we identify mitochondrial protein import capacity as a regulator of redox-dependent signalling in tumour cells. We show that the mitochondrial import motor component TIMM44, which is upregulated in angiogenesis-driven tumours, drives respiratory remodelling without increasing mitochondrial abundance. This mitochondrial reprogramming establishes a redox-competent state that activates ASK1-p38MAPK, resulting in SP1-dependent upregulation of VEGFA independently of HIF stabilization. Importantly, induction of mitochondrial biogenesis via PGC-1α fails to recapitulate this response despite increased active mitochondrial content, demonstrating that abundance of active mitochondria or generic metabolic activation is insufficient to drive this HIF-independent transcription. Collectively, our findings identify mitochondrial protein import process as an active signalling regulator rather than a passive housekeeping role, which links mitochondrial proteostasis to redox-sensitive kinase activation and transcriptional control. This work highlights a non-canonical mitochondrial signalling mechanism through which cells couple organelle remodelling to gene expression programs.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, 221005, India",
    "Department of Ageing Research, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India",
    "Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, 221005, India; Corresponding author."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Tanvi Chaudhary"
    },
    {
      "affs": [
        1
      ],
      "name": "Sharath Mohan Bhat"
    },
    {
      "affs": [
        0
      ],
      "name": "Priyadarshika Pradhan"
    },
    {
      "affs": [
        1
      ],
      "name": "Manjunath B. Joshi"
    },
    {
      "affs": [
        2
      ],
      "name": "Devanjan Sinha"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/39253ga6ydy1z.bib",
  "cited_by": 0,
  "doi": "10.1016/j.redox.2026.104381",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2213231726003800",
  "id": "39253ga6ydy1z",
  "issns": [
    "2213-2317"
  ],
  "landing_url": "https://doi.org/10.1016/j.redox.2026.104381",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "lcc",
      "R5-920"
    ],
    [
      "openalex",
      "1312|Mitochondrial Function and Pathology"
    ]
  ],
  "openalex": "W7206217592",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/39253ga6ydy1z.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:16Z",
      "native_id": "f0c5cf64dce046888d9a83c8ce189450",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.redox.2026.104381"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Mitochondrial Function and Pathology",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Non-canonical activation of VEGFA through TIMM44-dependent mitochondrial remodelling",
  "title_text": "Non-canonical activation of VEGFA through TIMM44-dependent mitochondrial remodelling",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:16Z",
  "url": "https://research.draconitic.com/paper/39253ga6ydy1z",
  "venue": "Redox Biology",
  "versions": []
}