{
  "abstract": "The 2{delta} family of auxiliary voltage-gated calcium channel (VGCC) subunits have critical but incompletely understood roles in brain function. Parvalbumin-positive (PV+) interneurons in the hippocampus highly express the 2{delta}-2 isoform, and mice lacking 2{delta}-2 exhibit spontaneous seizures. Thus, we examined PV+ neuron-mediated synaptic inhibition in acutely prepared brain slices from 2{delta}-2 knockout (KO) mice. In the inner molecular layer of the dentate gyrus, 2{delta}-2 KO mice demonstrated an increase in the excitation/inhibition ratio of synaptic inputs onto granule cells. We then used optogenetics to activate PV+ interneurons, which produced dramatically smaller inhibitory synaptic currents in granule cells from 2{delta}-2 KO mice. There was a reduction in PV+ inputs onto granule cells as determined by immunostaining. Functionally, these inputs had a lower probability of GABA release and a decreased readily releasable pool of vesicles compared to littermate controls. VGCC coupling to presynaptic vesicle release was also reduced in dentate gyrus PV+ cells in 2{delta}-2 KO mice, based on manipulations of intracellular and extracellular calcium. Together, our data indicate that 2{delta}-2 plays a critical role in PV+ interneuron-mediated synaptic inhibition, which may contribute to seizures in 2{delta}-2 mutant mice.",
  "abstract_shown": true,
  "affiliations": [
    "Oregon Health & Science University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "A. J. Ellingson"
    },
    {
      "name": "E. C. Jerome"
    },
    {
      "name": "A. A. Gallagher"
    },
    {
      "affs": [
        0
      ],
      "name": "E. Schnell"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/39ch31f512hxm.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.08.31.748347",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.08.31.748347v1.full",
  "id": "39ch31f512hxm",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.08.31.748347v1",
  "language": null,
  "licence": "CC0-1.0",
  "licence_label": "CC0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/publicdomain/zero/1.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2804|Neuroscience and Neuropharmacology Research"
    ]
  ],
  "openalex": "W7208780304",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.08.31.748347v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-31",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/39ch31f512hxm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:28Z",
      "native_id": "10.64898/2026.08.31.748347",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.08.31.748347v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "α2δ-2 mediates coupling of presynaptic calcium entry to vesicle release in hippocampal parvalbumin-expressing interneurons",
  "title_text": "α2δ-2 mediates coupling of presynaptic calcium entry to vesicle release in hippocampal parvalbumin-expressing interneurons",
  "type": "preprint",
  "updated_at": "2026-10-30T12:19:28Z",
  "url": "https://research.draconitic.com/paper/39ch31f512hxm",
  "venue": "bioRxiv",
  "versions": []
}