{
  "abstract": "Helicobacter pylori ( H. pylori ) is a chronic gastric mucosa colonizer that leads to the Correa cascade of gastric adenocarcinoma progression: chronic gastritis, intestinal metaplasia, and dysplasia. Signal transducer and activator of transcription 1 (STAT1) is one of the key mediators at the host immunity-tumor cell interface. The interaction of H. pylori with pattern recognition receptors on gastric epithelial cells induces tyrosine phosphorylation of STAT1 by Janus kinase (JAK), which in turn leads to dimerization and nuclear translocation of the protein, resulting in the suppression of pathogen survival enabled by interferon (IFN)-regulatory transcriptional programs. Ironically, STAT1 has a dual role in gastric carcinogenesis in a context-dependent manner: in the early disease, it acts as a tumor suppressor by facilitating apoptosis and cell-cycle arrest in gastric lesions, but in the advanced disease, it plays a role in immune evasion and tumor progression through the expression of programed death-ligand 1 (PD-L1) and tumor microenvironment (TME) modulation. This review critically assesses how H. pylori manipulates the STAT1 signaling during the infection process, crosstalk between the STAT1 and STAT3 pathways, and the future use of this understanding to therapeutically target and develop biomarkers. New strategies such as small-molecule STAT inhibitors, combination immunotherapy, and artificial intelligence (AI)-based biomarker discovery are discussed, as well as existing limitations and future research directions.",
  "abstract_shown": true,
  "affiliations": [
    "Science and Education Department, Kunshan Maternity and Children’s Health Care Hospital",
    "Department of General Surgery, Kunshan Hospital Affiliated to Jiangsu University",
    "Department of Clinical Laboratory, Jinxi People’s Hospital of Kunshan",
    "Department of Clinical Laboratory, Kunshan Hospital Affiliated to Jiangsu University",
    "Science and Technology Talent Department, Kunshan Hospital Affiliated to Jiangsu University",
    "Central Laboratory, The Fourth People’s Hospital of Shenzhen"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Wei Han"
    },
    {
      "affs": [
        2
      ],
      "name": "Hongzheng He"
    },
    {
      "affs": [
        3
      ],
      "name": "Bei Ye"
    },
    {
      "affs": [
        3
      ],
      "name": "Yilin Sun"
    },
    {
      "affs": [
        3
      ],
      "name": "XiuPing Wang"
    },
    {
      "affs": [
        4
      ],
      "name": "Tingting Liu"
    },
    {
      "affs": [
        5
      ],
      "name": "Hanwei Cui"
    },
    {
      "affs": [
        3
      ],
      "name": "Jianjun Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/39h1rg1vmrva2.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1679212",
  "fulltext_url": null,
  "id": "39h1rg1vmrva2",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1679212/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Helicobacter pylori-related gastroenterology studies"
    ]
  ],
  "openalex": "W7223180906",
  "pdf_url": "https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1679212/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-22",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/39h1rg1vmrva2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:17Z",
      "native_id": "10.3389/fimmu.2026.1679212",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1679212/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Helicobacter pylori-related gastroenterology studies",
      "subfield": "surgery"
    }
  ],
  "title": "The STAT1 lexicon: translating signaling codes in H. pylori-driven gastric carcinogenesis",
  "title_text": "The STAT1 lexicon: translating signaling codes in H. pylori-driven gastric carcinogenesis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:17Z",
  "url": "https://research.draconitic.com/paper/39h1rg1vmrva2",
  "venue": "Frontiers in Immunology",
  "versions": []
}