{
  "abstract": "To evaluate the diagnostic performance of multi-modal ultrasound imaging, combining transrectal ultrasound (TRUS), shear wave elastography (SWE), and contrast-enhanced ultrasound (CEUS), for differentiating benign and malignant prostate lesions, and to provide new evidence for the early diagnosis of prostate cancer. A total of 85 patients who prospectively underwent multi-modal ultrasound examination, ultrasound-guided prostate biopsy, and pathological and immunohistochemical marker detection at our hospital between September 2022 and June 2023 were included. All ultrasound examinations and biopsies were performed within a 2-week interval. The diagnostic performance of TRUS, SWE, CEUS, and multi-modal ultrasound imaging was compared, with 95% confidence intervals (CIs) calculated for all accuracy measures. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were 89.80% (95% CI: 77.81 to 95.83), 86.11% (95% CI: 70.98-93.91), 88.24%, 89.80%, and 86.11% for TRUS; 85.71% (95% CI: 72.87-92.96), 72.22% (95% CI: 55.72-84.09), 80.00%, 80.77%, and 78.79% for SWE; 93.88% (95% CI: 83.13-97.97), 91.67% (95% CI: 77.46-97.20), 92.94%, 93.88%, and 91.67% for CEUS; and 97.96% (95% CI: 89.21-99.65), 94.44% (95% CI: 81.34-98.48), 96.47%, 96.00%, and 97.14% for multi-modal ultrasound imaging, respectively. The areas under the receiver operating characteristic curves (AUCs) were 0.880 (95% CI: 0.808-0.952), 0.790 (95% CI: 0.694-0.886), 0.928 (95% CI: 0.872-0.984), and 0.962 (95% CI: 0.924-1.000) for TRUS, SWE, CEUS, and multi-modal ultrasound imaging, respectively. The diagnostic performance of multi-modal ultrasound was significantly superior to that of TRUS and SWE (P < .05). Multi-modal ultrasound imaging demonstrates complementary diagnostic advantages, particularly for prostate tumors with atypical ultrasound features that are difficult to diagnose by a single modality. For these tumors, multi-modal ultrasound imaging improves diagnostic accuracy and provides a reliable basis for the differential diagnosis of prostate tumors, warranting further clinical application.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Ultrasound, Deyang People's Hospital, Deyang, Sichuan, China.",
    "Medical Records Statistics Management Section, Deyang People's Hospital, Deyang, Sichuan, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jin Li",
      "orcid": "0009-0009-0260-7926"
    },
    {
      "affs": [
        0
      ],
      "name": "Kang He"
    },
    {
      "affs": [
        1
      ],
      "name": "Hao Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Dejun Hu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xin Wei"
    },
    {
      "affs": [
        1
      ],
      "name": "Le Luo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/39hszf4fx8djm.bib",
  "cited_by": 0,
  "doi": "10.1097/md.0000000000051135",
  "fulltext_url": "https://europepmc.org/articles/PMC13681124",
  "id": "39hszf4fx8djm",
  "issns": [
    "0304-5412",
    "1536-5964"
  ],
  "landing_url": "https://europepmc.org/article/MED/42888615",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2741|Ultrasound Imaging and Elastography"
    ]
  ],
  "openalex": "W7222495613",
  "pdf_url": "https://europepmc.org/articles/PMC13681124?pdf=render",
  "pmcid": "PMC13681124",
  "pmid": "42888615",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/39hszf4fx8djm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42888615",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42888615"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Ultrasound Imaging and Elastography",
      "subfield": "imaging"
    }
  ],
  "title": "Diagnosis of prostate cancer by multi-modal ultrasound imaging.",
  "title_text": "Diagnosis of prostate cancer by multi-modal ultrasound imaging.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/39hszf4fx8djm",
  "venue": "Medicine",
  "versions": []
}