{
  "abstract": "Background\n\nAccurate assessment of hidradenitis suppurativa (HS) severity is crucial for individualized management, yet conventional clinical grading may underestimate disease extent due to subclinical lesions. Ultrasound enables visualization of deep abscesses and tunnels and may provide additional prognostic information.Materials and methods\n\nSixty-eight patients with HS underwent standardized clinical and ultrasonographic evaluation. Disease severity was classified using the International Hidradenitis Suppurativa Severity Score System (IHS4) and the modified Sonographic Scoring of HS (mSOS-HS). Concordance between the two systems was assessed, and ultrasonographic grading and features were analyzed in relation to achievement of IHS4-55 at week 12.Results\n\nThe mSOS-HS classified 18 patients (26.5%) as having more severe disease than IHS4. The two grading systems showed statistically significant agreement, with the Kappa value approaching the threshold for moderate agreement (Kappa = 0.395, 95% CI: 0.204-0.586, p < 0.001). Patients with higher mSOS-HS grades were less likely to achieve IHS4-55 at week 12 (p = 0.014). Among specific ultrasonographic features, the railway sign, defined as parallel hyperechoic lines within tunnel-like structures, was significantly associated with failure to achieve IHS4-55 (p = 0.003).Conclusion\n\nUltrasonography reveals subclinical HS involvement beyond clinical examination and provides prognostic information for treatment response. The mSOS-HS complements IHS4 for comprehensive disease staging, while the railway sign may serve as an imaging biomarker for unfavorable response across real-world treatment settings.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.",
    "Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Juncheng Wang",
      "orcid": "0000-0003-0972-9511"
    },
    {
      "affs": [
        1
      ],
      "name": "Jing Qin",
      "orcid": "0000-0002-6029-7673"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiao Ma",
      "orcid": "0000-0003-3982-3744"
    },
    {
      "affs": [
        1
      ],
      "name": "Mengyuan Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Jie Liu",
      "orcid": "0000-0001-8219-2429"
    },
    {
      "affs": [
        1
      ],
      "name": "Qingli Zhu",
      "orcid": "0000-0002-0618-2381"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/39t0c7p13w85x.bib",
  "cited_by": 0,
  "doi": "10.1111/srt.70387",
  "fulltext_url": "https://europepmc.org/articles/PMC13721158",
  "id": "39t0c7p13w85x",
  "issns": [
    "0909-752X",
    "1600-0846"
  ],
  "landing_url": "https://europepmc.org/article/MED/42960977",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://europepmc.org/articles/PMC13721158?pdf=render",
  "pmcid": "PMC13721158",
  "pmid": "42960977",
  "published": "2026-10-30",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/39t0c7p13w85x.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:46Z",
      "native_id": "MED:42960977",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42960977"
    },
    {
      "first_seen": "2026-11-03T12:21:54Z",
      "native_id": "PMC13721158",
      "source": "pmc",
      "url": "https://doi.org/10.1111/srt.70387"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:2708|Dermatology and Skin Diseases",
      "subfield": "general"
    }
  ],
  "title": "Comparison of Clinical and Ultrasonographic Severity Assessment in Hidradenitis Suppurativa: Prognostic Implications.",
  "title_text": "Comparison of Clinical and Ultrasonographic Severity Assessment in Hidradenitis Suppurativa: Prognostic Implications.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:54Z",
  "url": "https://research.draconitic.com/paper/39t0c7p13w85x",
  "venue": "Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)",
  "versions": []
}