{
  "abstract": "The renal dopaminergic system (RDS) promotes natriuresis, diuresis, and exerts anti-inflammatory effects. High-fat diet (HFD) intake triggers the renin–angiotensin system (RAS). The aim of this study was to determine whether losartan (L) prevents RDS-RAS alteration and its impact on blood pressure and renal injury induced by HFD. Male Sprague–Dawley rats studied for 8 weeks were assigned to four groups: control (C; n = 4); HFD (n = 6): 50% w/w of bovine fat added to the standard diet; control + losartan (CL; n = 4): 30 mg/kg/day of L dissolved in drinking water; and HFD + losartan (HFDL; n = 6): HFD + CL. (Mean ± SD; p < 0.05). L prevented the following: HFD-induced increases in systolic blood pressure (SBP) and L-Dopa/dopamine urinary index (HFD vs. C, p < 0.01; HFDL vs. HFD, p < 0.01); lower expression of OCTN-1/2/3 (HFD vs. C, p < 0.01; HFDL vs. HFD, p < 0.05); overexpression of D1DR and Na+/K+-ATPase (HFD vs. C, p < 0.01; HFDL vs. HFD: D1DR p < 0.01; Na+/K+-ATPase p < 0.05), NF-κB1 and TGF-β1 (HFDL vs. HFD, p < 0.01). L mitigated proximal tubular alterations and interstitial fibrosis (HFDL vs. HFD, p < 0.01). Under chronic HFD intake, early L administration prevented renal dopaminergic system alterations and SBP elevation, and attenuated renal inflammation and interstitial fibrosis, reflecting its nephroprotective effects.",
  "abstract_shown": true,
  "affiliations": [
    "Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Ciencias Biológicas, Cátedra de Anatomía e Histología, Buenos Aires 1113, Argentina",
    "Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Instituto de Fisiopatología y Bioquímica Clínica (INFIBIOC), Laboratorio de Síndrome Metabólico Experimental, Buenos Aires 1113, Argentina",
    "Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Farmacología, Cátedra de Farmacología, Buenos Aires 1113, Argentina",
    "Pontificia Universidad Católica Argentina, Especialización en Nefrología, Facultad de Ciencias Médicas, Buenos Aires 1113, Argentina",
    "Universidad de Buenos Aires/Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto Alberto C. Taquini de Investigaciones en Medicina Traslacional (IATIMET), Buenos Aires 1113, Argentina"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Silvana M. Cantú"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hyun J. Lee"
    },
    {
      "affs": [
        2
      ],
      "name": "Christian Höcht",
      "orcid": "0000-0001-8992-9841"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Adriana S. Donoso"
    },
    {
      "affs": [
        3
      ],
      "name": "Rodolfo Valtuille",
      "orcid": "0000-0003-2434-9226"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ana M. Puyó",
      "orcid": "0000-0002-5992-9792"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Marcelo R. Choi",
      "orcid": "0000-0003-2909-8534"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/39y3j6rp5fj8m.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27209098",
  "fulltext_url": "https://europepmc.org/articles/PMC13705034",
  "id": "39y3j6rp5fj8m",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/20/9098",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2705|Renin-Angiotensin System Studies"
    ]
  ],
  "openalex": "W7221806114",
  "pdf_url": "https://europepmc.org/articles/PMC13705034?pdf=render",
  "pmcid": "PMC13705034",
  "pmid": "42941868",
  "published": "2026-10-14",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/39y3j6rp5fj8m.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:55Z",
      "native_id": "10.3390/ijms27209098",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/20/9098"
    },
    {
      "first_seen": "2026-10-30T12:22:12Z",
      "native_id": "MED:42941868",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42941868"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Renin-Angiotensin System Studies",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Effects of Losartan on Renal Dopaminergic and Renin–Angiotensin System Alterations Induced by a High-Fat Diet in Sprague-Dawley Rats",
  "title_text": "Effects of Losartan on Renal Dopaminergic and Renin–Angiotensin System Alterations Induced by a High-Fat Diet in Sprague-Dawley Rats",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:12Z",
  "url": "https://research.draconitic.com/paper/39y3j6rp5fj8m",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}