{
  "abstract": "Background\n\nPolycystic ovary syndrome (PCOS) is associated with metabolic abnormalities and increased long-term cardiovascular risk. Endothelial dysfunction is considered an early event in atherogenesis, and soluble E-selectin has been proposed as a marker of endothelial activation. However, its role in cardiovascular risk assessment in PCOS remains uncertain.Aim\n\nThe study aimed to compare circulating soluble E-selectin levels between women with PCOS and healthy controls and evaluate their association with metabolic parameters and QRISK3-based cardiovascular risk scores.Settings and design\n\nProspective hospital-based case-control study.Materials and methods\n\nTwo hundred women with PCOS diagnosed according to the Rotterdam criteria and 50 age-matched healthy controls aged 18-40 years were enrolled. Clinical assessment, anthropometry, fasting blood glucose, HbA1c, lipid profile, C-reactive protein and soluble E-selectin levels were evaluated. Estimated 10-year cardiovascular risk was calculated using the QRISK3 algorithm.Statistical analysis used\n\nGroup comparisons, correlation analyses and multivariable linear regression were performed.Results\n\nMean soluble E-selectin levels were comparable between women with PCOS and controls (0.61 ± 0.33 vs. 0.61 ± 0.29 ng/mL, P = 0.935). Within the PCOS group, soluble E-selectin correlated positively with HbA1c (r = 0.326, P = 0.001) and fasting blood glucose (r = 0.271, P = 0.001), while no significant associations were observed with anthropometric measures, lipid parameters, blood pressure or QRISK3 scores. In multivariable analysis, fasting blood glucose remained independently associated with soluble E-selectin.Conclusion\n\nSoluble E-selectin levels did not differ between women with PCOS and controls and showed limited associations with cardiovascular risk factors. These findings do not support a major role for soluble E-selectin in cardiovascular risk assessment among young women with PCOS.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.",
    "Reproductive Biology, All India Institute of Medical Sciences, New Delhi, India.",
    "Cardiology, All India Institute of Medical Sciences, New Delhi, India.",
    "National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Nilanchali Singh"
    },
    {
      "affs": [
        0
      ],
      "name": "Iman Dandapath"
    },
    {
      "affs": [
        0
      ],
      "name": "Akanksha Gupta"
    },
    {
      "affs": [
        1
      ],
      "name": "Surabhi Gupta"
    },
    {
      "affs": [
        0
      ],
      "name": "Rosemary Jha"
    },
    {
      "affs": [
        2
      ],
      "name": "Deepti Siddharthan"
    },
    {
      "affs": [
        3
      ],
      "name": "Ashwani Kumar Mishra"
    },
    {
      "affs": [
        0
      ],
      "name": "D Kathiravan"
    },
    {
      "affs": [
        0
      ],
      "name": "Neeta Singh"
    },
    {
      "affs": [
        0
      ],
      "name": "Zakiya Zakiya"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3afzwxqa6j9g5.bib",
  "cited_by": 0,
  "doi": "10.4103/jhrs.jhrs_56_26",
  "fulltext_url": "https://europepmc.org/articles/PMC13690305",
  "id": "3afzwxqa6j9g5",
  "issns": [
    "0974-1208",
    "1998-4766"
  ],
  "landing_url": "https://europepmc.org/article/MED/42924328",
  "language": "eng",
  "licence": "CC-BY-NC-SA",
  "licence_label": "CC BY-NC-SA",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2743|Ovarian function and disorders"
    ]
  ],
  "openalex": "W7214983151",
  "pdf_url": "https://europepmc.org/articles/PMC13690305?pdf=render",
  "pmcid": "PMC13690305",
  "pmid": "42924328",
  "published": "2026-07-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3afzwxqa6j9g5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:02Z",
      "native_id": "MED:42924328",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42924328"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2743|Ovarian function and disorders",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Soluble E-selectin and QRISK3-based Cardiovascular Risk Assessment in Women with Polycystic Ovary Syndrome: A Prospective Case-control Study from India.",
  "title_text": "Soluble E-selectin and QRISK3-based Cardiovascular Risk Assessment in Women with Polycystic Ovary Syndrome: A Prospective Case-control Study from India.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:02Z",
  "url": "https://research.draconitic.com/paper/3afzwxqa6j9g5",
  "venue": "Journal of human reproductive sciences",
  "versions": []
}