{
  "abstract": "Background and Hypothesis: Clinical high risk (CHR) for psychosis status is associated with poor social functioning. Previous studies suggest that childhood trauma and reduced amplitude of the P300 event-related potential (ERP) component elicited by infrequent target stimuli (P3b) are associated with poor social function. Here, we examined whether reduced P3b mediates the relationship between reported trauma history and social function in CHR individuals, possibly reflecting the impact of past trauma on neurophysiological processes subserving attention that ultimately influence social functioning.\n\nStudy Design: Target P3b ERP amplitudes from visual and auditory oddball tasks acquired at baseline in the Accelerating Medicines Partnership Schizophrenia (AMP SCZ) study were analyzed. The mediating effects of auditory and visual P3b amplitude on the relationship between trauma history (Childhood Trauma Questionnaire total score) and Negative Symptom Inventory-Psychosis Risk Asociality (NSI-PR) as well as social functioning (Global Functioning: Social (GFS) scores were examined.\n\nStudy Results: Data from 931 CHR participants (average age 21.29 years, 36.3% male) were included in mediation analyses. Visual P3b showed significant (P < .05) mediation of the relationship between trauma load and GFS score (5.4% mediation) as well as mediation of the relationship between trauma history and NSI-PR asociality (9.3% mediation). Auditory P3b did not significantly mediate either relationship.\n\nConclusions: These results suggest that visual, but not auditory, P3b mediates the relationship between past trauma load and social functioning in CHR, suggesting the effect of trauma on the neurophysiological processes subserving visual target detection may contribute to social functioning deficits in CHR individuals.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 58,
  "authors": [
    {
      "name": "Jason Smucny"
    },
    {
      "name": "Holly K Hamilton"
    },
    {
      "name": "Suzie Lavoie"
    },
    {
      "name": "Thomas J Whitford",
      "orcid": "0000-0001-9187-3816"
    },
    {
      "name": "Luis Alameda"
    },
    {
      "name": "Öznur Baştürk"
    },
    {
      "name": "Grace R Jacobs"
    },
    {
      "name": "Ines Lepreux"
    },
    {
      "name": "Teya Petrova"
    },
    {
      "name": "Lotta-Katrin Pries"
    },
    {
      "name": "Guilia Trotta"
    },
    {
      "name": "Sandra Vieira"
    },
    {
      "name": "Jean Addington"
    },
    {
      "name": "Sylvain Bouix"
    },
    {
      "name": "Nicholas J K Breitborde"
    },
    {
      "name": "Matthew R Broome"
    },
    {
      "name": "Kristin S Cadenhead",
      "orcid": "0000-0002-5952-4605"
    },
    {
      "name": "Monica E Calkins",
      "orcid": "0000-0002-0546-0263"
    },
    {
      "name": "Ricardo E Carrión",
      "orcid": "0000-0002-6393-392X"
    },
    {
      "name": "Rolando I Castillo-Passi"
    },
    {
      "name": "Jimmy Choi"
    },
    {
      "name": "Philippe Conus"
    },
    {
      "name": "Cheryl M Corcoran"
    },
    {
      "name": "Covadonga M Díaz-Caneja",
      "orcid": "0000-0001-8538-3175"
    },
    {
      "name": "Lauren M Ellman"
    },
    {
      "name": "Paolo Fusar-Poli"
    },
    {
      "name": "Louise B Glenthøj",
      "orcid": "0000-0003-3621-8450"
    },
    {
      "name": "Leslie E Horton"
    },
    {
      "name": "Joseph Kambeitz",
      "orcid": "0000-0002-8988-3959"
    },
    {
      "name": "Tina Kapur"
    },
    {
      "name": "Matcheri S Keshavan"
    },
    {
      "name": "Minah Kim"
    },
    {
      "name": "Sung-Wan Kim",
      "orcid": "0000-0002-6739-2163"
    },
    {
      "name": "Jun Soo Kwon",
      "orcid": "0000-0002-1060-1462"
    },
    {
      "name": "Daniel Mamah"
    },
    {
      "name": "Vijay A Mittal",
      "orcid": "0000-0001-9017-5119"
    },
    {
      "name": "Ofer Pasternak"
    },
    {
      "name": "Godfrey D Pearlson",
      "orcid": "0000-0002-7525-5185"
    },
    {
      "name": "Jesus Perez"
    },
    {
      "name": "David R Roalf"
    },
    {
      "name": "Jason Schiffman"
    },
    {
      "name": "Jai Shah",
      "orcid": "0000-0002-7549-6990"
    },
    {
      "name": "Steven M Silverstein",
      "orcid": "0000-0002-0699-0960"
    },
    {
      "name": "Stefan Smesny"
    },
    {
      "name": "Gregory P Strauss"
    },
    {
      "name": "Judy L Thompson"
    },
    {
      "name": "Daniel H Wolf",
      "orcid": "0000-0002-9731-8781"
    },
    {
      "name": "Tianhong Zhang",
      "orcid": "0000-0002-5379-7119"
    },
    {
      "name": "Carrie E Bearden",
      "orcid": "0000-0002-8516-923X"
    },
    {
      "name": "John M Kane",
      "orcid": "0000-0002-2628-9442"
    },
    {
      "name": "René S Kahn"
    },
    {
      "name": "Patrick D McGorry"
    },
    {
      "name": "Barnaby Nelson"
    },
    {
      "name": "Martha E Shenton"
    },
    {
      "name": "Scott W Woods"
    },
    {
      "name": "The Accelerating Medicines Partnership Schizophrenia (AMP SCZ)"
    },
    {
      "name": "Gregory A Light"
    },
    {
      "name": "Daniel H Mathalon"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3ajm8hp3p46qe.bib",
  "cited_by": 0,
  "doi": "10.1093/schizbullopen/sgag041",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13738217/",
  "id": "3ajm8hp3p46qe",
  "issns": [
    "2632-7899"
  ],
  "landing_url": "https://doi.org/10.1093/schizbullopen/sgag041",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "AcademicSubjects/MED00800"
    ],
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2738|Schizophrenia research and treatment"
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  "openalex": "W7221439012",
  "pdf_url": "https://academic.oup.com/schizbullopen/advance-article-pdf/doi/10.1093/schizbullopen/sgag041/71840068/sgag041.pdf",
  "pmcid": "PMC13738217",
  "pmid": "42992169",
  "published": "2026-10-11",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/3ajm8hp3p46qe.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:23:14Z",
      "native_id": "PMC13738217",
      "source": "pmc",
      "url": "https://doi.org/10.1093/schizbullopen/sgag041"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Schizophrenia research and treatment",
      "subfield": "psychiatry"
    }
  ],
  "title": "Visual Target P3b Amplitude Mediates the Relationship between Childhood Traumatic Experiences and Social Functioning in People at Clinical High Risk for Psychosis",
  "title_text": "Visual Target P3b Amplitude Mediates the Relationship between Childhood Traumatic Experiences and Social Functioning in People at Clinical High Risk for Psychosis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:23:14Z",
  "url": "https://research.draconitic.com/paper/3ajm8hp3p46qe",
  "venue": "Schizophrenia Bulletin Open",
  "versions": []
}