{
  "abstract": "BackgroundTrichosporon species have emerged as opportunistic pathogens, causing life-threatening invasive infections. However, epidemiological data from South China remain limited. This multicenter study investigates the species distribution, genotypic characteristics, and antifungal susceptibility profiles of clinical Trichosporon isolates from this region.MethodsA total of 223 unique clinical Trichosporon isolates were collected from 18 centers in five South China provinces. These isolates were identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and sequencing of the intergenic spacer 1 (IGS1) region. The Trichosporon asahii isolates were further analyzed through IGS1 sequence analysis for genotyping. The minimum inhibitory concentrations (MICs) of six antifungal agents were determined using the broth microdilution method outlined by the Clinical and Laboratory Standards Institute (CLSI). Whole-genome sequencing (WGS) was performed on isolates with high fluconazole MICs and on randomly selected low-MIC isolates to characterize ERG11 mutations.ResultsIGS1 sequencing identified 220 of the 223 isolates to the species level, representing eight species, with T. asahii predominating (171, 77.7%). The species-level concordance between MALDI-TOF MS and IGS1 sequencing was 85.5% (188/220), with substantial interspecies variation. Genotypes 1 (32.7%) and 3 (32.2%) co-predominated among T. asahii isolates, with no significant association found between genotype and specimen source (P = 0.663). Voriconazole was the most active agent, with a MIC90 of 0.125 μg/mL and a geometric mean (GM) of 0.06 μg/mL. High fluconazole MICs were consistently associated with specific ERG11 substitutions: Y133F in T. dohaense and L229I, V132A, and Y133F in T. asteroides.ConclusionsT. asahii is the predominant clinical Trichosporon species in South China. Voriconazole is the most effective antifungal agent against Trichosporon. Species-specific ERG11 polymorphisms may be associated with elevated fluconazole MICs.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China",
    "Department of Laboratory Medicine and Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China",
    "Department of Clinical Laboratory Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China",
    "Department of Clinical Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, China",
    "Department of Clinical Laboratory Medicine, People’s Hospital of Boluo County, Huizhou, China",
    "Department of Clinical Laboratory Medicine, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China",
    "Department of Clinical Laboratory Medicine, The First People’s Hospital of Yulin, Yulin, China",
    "Department of Clinical Laboratory, Heyuan Hospital of Traditional Chinese Medicine, Heyuan, China",
    "Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China",
    "0Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yangyang Qiao"
    },
    {
      "affs": [
        1
      ],
      "name": "Jiarong Zhan"
    },
    {
      "affs": [
        2
      ],
      "name": "Kaixuan Yuan"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiankai Deng"
    },
    {
      "affs": [
        0
      ],
      "name": "Yaqin Peng"
    },
    {
      "affs": [
        3
      ],
      "name": "Huilin Yang"
    },
    {
      "affs": [
        4
      ],
      "name": "Shiqin Yang"
    },
    {
      "affs": [
        5
      ],
      "name": "Bingshao Liang"
    },
    {
      "affs": [
        6
      ],
      "name": "Danping Qiu"
    },
    {
      "affs": [
        7
      ],
      "name": "Lanping Zhang"
    },
    {
      "affs": [
        8
      ],
      "name": "Wenying Cai"
    },
    {
      "affs": [
        9
      ],
      "name": "Yanfang Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Penghao Guo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3aw09t44br7z2.bib",
  "cited_by": 0,
  "doi": "10.3389/fcimb.2026.1982885",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fcimb.2026.1982885/full",
  "id": "3aw09t44br7z2",
  "issns": [
    "2235-2988"
  ],
  "landing_url": "https://doi.org/10.3389/fcimb.2026.1982885",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QR1-502"
    ],
    [
      "openalex",
      "2725|Antifungal resistance and susceptibility"
    ]
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  "openalex": "W7223408287",
  "pdf_url": "https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1982885/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "Frontiers Media S.A.",
  "ris": "https://research.draconitic.com/paper/3aw09t44br7z2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:11Z",
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|Antifungal resistance and susceptibility",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Species distribution and antifungal susceptibility profiles of Trichosporon species: a multicenter study of 223 clinical isolates from South China",
  "title_text": "Species distribution and antifungal susceptibility profiles of Trichosporon species: a multicenter study of 223 clinical isolates from South China",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:11Z",
  "url": "https://research.draconitic.com/paper/3aw09t44br7z2",
  "venue": "Frontiers in Cellular and Infection Microbiology",
  "versions": []
}