{
  "abstract": "Ovarian cancer remains the most lethal gynecologic malignancy due to its asymptomatic progression, limited screening modalities, and late-stage diagnosis. Although initial responses to platinum-based chemotherapy are common, recurrence and multidrug resistance are nearly universal, necessitating a shift toward biomarker-guided, precision-based interventions. This review synthesizes current evidence on the evolving landscape of ovarian cancer treatment, with emphasis on molecular pathogenesis, histotype-specific vulnerabilities, and advances in therapeutic strategies. Focus is placed on the clinical integration of poly (ADP-ribose) polymerase (PARP) inhibitors, vascular endothelial growth factor (VEGF)-targeting agents, immune checkpoint inhibitors, and antibody-drug conjugates, alongside emerging platforms such as liquid biopsy, artificial intelligence-enhanced diagnostics, and histotype-driven targeted therapies. Translational insights from other malignancies were utilized to highlight future directions for ovarian cancer, including dual pathway targeting, immune and epigenetic modulation, and receptor-guided cytotoxic delivery. Collectively, these advances demonstrate how precision oncology is advancing ovarian cancer treatment, with the potential to improve survival outcomes while preserving quality of life.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Obstetrics and Gynecology, Wayne State University School of Medicine Karmanos Cancer Institute, Detroit, MI, 48201, USA. gsaed@med.wayne.edu.",
    "Department of Gynecologic Oncology, Karmanos Cancer Institute, Detroit, MI, 48201, USA. gsaed@med.wayne.edu.",
    "Department of Obstetrics and Gynecology, University of Jordan School of Medicine, 226 Queen Rania Al Abdulla St, Amman, 11942, Jordan. gsaed@med.wayne.edu.",
    "Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA.",
    "Department of Obstetrics and Gynecology, University of Jordan School of Medicine, 226 Queen Rania Al Abdulla St, Amman, 11942, Jordan.",
    "Department of Gynecologic Oncology, Karmanos Cancer Institute, Detroit, MI, 48201, USA."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Ghassan M Saed"
    },
    {
      "affs": [
        3
      ],
      "name": "Laura Detti"
    },
    {
      "affs": [
        4
      ],
      "name": "Dina Massad"
    },
    {
      "affs": [
        4
      ],
      "name": "Asma Basha"
    },
    {
      "affs": [
        5
      ],
      "name": "Robert T Morris"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3b0f4b6fq5ffq.bib",
  "cited_by": 0,
  "doi": "10.1186/s13048-026-02165-z",
  "fulltext_url": "https://europepmc.org/articles/PMC13689302",
  "id": "3b0f4b6fq5ffq",
  "issns": [
    "1757-2215"
  ],
  "landing_url": "https://europepmc.org/article/MED/42907928",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RG1-991"
    ],
    [
      "openalex",
      "2743|Ovarian cancer diagnosis and treatment"
    ]
  ],
  "openalex": "W7171205124",
  "pdf_url": "https://europepmc.org/articles/PMC13689302?pdf=render",
  "pmcid": "PMC13689302",
  "pmid": "42907928",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/3b0f4b6fq5ffq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:59Z",
      "native_id": "MED:42907928",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42907928"
    },
    {
      "first_seen": "2026-10-30T13:46:18Z",
      "native_id": "03e5c3692b5447328e5aea22ca1028f5",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s13048-026-02165-z"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2743|Ovarian cancer diagnosis and treatment",
      "subfield": "reproductive-child"
    }
  ],
  "title": "From cytoreduction to precision oncology: evolution of ovarian cancer therapy.",
  "title_text": "From cytoreduction to precision oncology: evolution of ovarian cancer therapy.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:20:50Z",
  "url": "https://research.draconitic.com/paper/3b0f4b6fq5ffq",
  "venue": "Journal of ovarian research",
  "versions": []
}