{
  "abstract": "Background/Objectives: Classical major histocompatibility complex (MHC)-restricted T cells play essential roles in tuberculosis (TB) immunity. Characterizing the antigen targets, dominant epitopes, and MHC restriction of protective T-cell responses is important for understanding TB immunity and next-generation TB vaccine development. Methods: We recently used vaccine screening in mice to identify Rv1387 (PPE20), Rv0287 (EsxG), Rv1788 (PE18), and Rv1886c (Ag85B) as protective antigens, and in this paper, we characterized the T-cell responses to these antigens in mice. Results: We first identified the full repertoire of CD4 and CD8 T-cell epitopes in C57BL/6 and BALB/c mice. We further defined the MHC class I and II restriction of immunodominant epitopes, enabling the development and validation of tetramers for probing cognate T-cell responses. Finally, we used these tetramers to contrast lung mucosal T-cell phenotypes in the setting of Bacillus Calmette-Guérin (BCG) and mRNA vaccination. Conclusions: These results define the T-cell epitopes and MHC restriction of next-generation TB vaccine antigens and contribute reagents for studying TB T-cell immunity.",
  "abstract_shown": true,
  "affiliations": [
    "Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Samuel J Vidal"
    },
    {
      "affs": [
        0
      ],
      "name": "Alejandro A Espinosa Perez",
      "orcid": "0009-0006-2877-1941"
    },
    {
      "affs": [
        0
      ],
      "name": "Ganad D Neka"
    },
    {
      "affs": [
        0
      ],
      "name": "Aleisha M G Roberts"
    },
    {
      "affs": [
        0
      ],
      "name": "Yu Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Lili Benitez Angeles",
      "orcid": "0009-0004-8736-5156"
    },
    {
      "affs": [
        0
      ],
      "name": "Hannah I Angulo Espinoza",
      "orcid": "0009-0000-7453-2622"
    },
    {
      "affs": [
        0
      ],
      "name": "Ellis A Strutton",
      "orcid": "0009-0002-1463-1455"
    },
    {
      "affs": [
        0
      ],
      "name": "Esther R Mbiwan",
      "orcid": "0009-0001-2292-3741"
    },
    {
      "affs": [
        0
      ],
      "name": "Jayeshbhai Chaudhari",
      "orcid": "0000-0002-1864-562X"
    },
    {
      "affs": [
        0
      ],
      "name": "Woojae Choi",
      "orcid": "0009-0007-5866-9099"
    },
    {
      "affs": [
        0
      ],
      "name": "Michelle Lifton",
      "orcid": "0000-0003-0279-2198"
    },
    {
      "affs": [
        0
      ],
      "name": "Pablo Penaloza-MacMaster"
    },
    {
      "affs": [
        0
      ],
      "name": "Dan H Barouch",
      "orcid": "0000-0001-5127-4659"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3b5jydxehvsd8.bib",
  "cited_by": 0,
  "doi": "10.3390/vaccines14100866",
  "fulltext_url": "https://europepmc.org/articles/PMC13709347",
  "id": "3b5jydxehvsd8",
  "issns": [
    "2076-393X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42931395",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2725|Tuberculosis Research and Epidemiology"
    ]
  ],
  "openalex": "W7215082084",
  "pdf_url": "https://europepmc.org/articles/PMC13709347?pdf=render",
  "pmcid": "PMC13709347",
  "pmid": "42931395",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3b5jydxehvsd8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42931395",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42931395"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|Tuberculosis Research and Epidemiology",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Epitope Mapping and MHC Restriction of Next-Generation Tuberculosis Vaccine Antigens in Mice.",
  "title_text": "Epitope Mapping and MHC Restriction of Next-Generation Tuberculosis Vaccine Antigens in Mice.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/3b5jydxehvsd8",
  "venue": "Vaccines",
  "versions": []
}