{
  "abstract": "Background\n\nFrailty is increasingly considered when evaluating surgical risk in older adults. However, evidence regarding whether frailty contributes to the risk of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis in elderly patients is limited.Objective\n\nWe aimed to evaluate whether preoperative frailty was associated with the development of post-ERCP pancreatitis (PEP) in elderly patients undergoing ERCP.Methods\n\nPatients aged 65 years or older who underwent ERCP for choledocholithiasis were retrospectively included. Frailty was assessed preoperatively using an electronic health record-based composite frailty index (EHR-CFI). PEP was defined according to the Cotton consensus criteria. Multivariable logistic regression, receiver operating characteristic (ROC) analysis, and net reclassification improvement (NRI) were used to explore the incremental contribution of frailty to PEP risk stratification.Results\n\nAmong 696 patients, 79 (11.4%) developed PEP. After multivariable adjustment, frailty was associated with higher odds of PEP (OR = 2.09, 95% CI 1.08-4.05; P = 0.028). Adding frailty to a reference model containing difficult biliary cannulation (DBC), sex, age, and the Charlson Comorbidity Index (CCI) improved discrimination for PEP, with the AUC increasing from 0.714 to 0.755 (DeLong test P = 0.031). The NRI was 0.516 (95% CI 0.218-0.748), suggesting improved risk classification.Conclusion\n\nPreoperative frailty assessed using EHR-CFI was independently associated with PEP and may provide additional value for risk stratification in elderly patients with choledocholithiasis undergoing ERCP.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastroenterology, Beijing Hospital, National Center for Gerontology, National Clinical Research Center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100730, People's Republic of China.",
    "Department of Cardiology, Beijing Hospital, National Center for Gerontology; National Clinical Research Center for Gerontology; The Key Laboratory of Geriatrics of NHC; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.",
    "Department of Geriatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, People's Republic of China.",
    "Department of Gastroenterology, Beijing Hospital, National Center for Gerontology, National Clinical Research Center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, Beijing, People's Republic of China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Fan Zhang"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Min Zeng",
      "orcid": "0000-0002-1490-9747"
    },
    {
      "affs": [
        3
      ],
      "name": "Yuhao Wan"
    },
    {
      "affs": [
        3
      ],
      "name": "Rui Gang"
    },
    {
      "affs": [
        3
      ],
      "name": "YuJun Xiong",
      "orcid": "0000-0001-9915-6723"
    },
    {
      "affs": [
        3
      ],
      "name": "XiaoYun Qin"
    },
    {
      "affs": [
        0
      ],
      "name": "Qingfeng Luo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3b78xq9vrk893.bib",
  "cited_by": 0,
  "doi": "10.2147/cia.s595446",
  "fulltext_url": "https://europepmc.org/articles/PMC13682304",
  "id": "3b78xq9vrk893",
  "issns": [
    "1176-9092",
    "1178-1998"
  ],
  "landing_url": "https://europepmc.org/article/MED/42904120",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Gallbladder and Bile Duct Disorders"
    ]
  ],
  "openalex": "W7221855484",
  "pdf_url": "https://europepmc.org/articles/PMC13682304?pdf=render",
  "pmcid": "PMC13682304",
  "pmid": "42904120",
  "published": "2026-10-16",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3b78xq9vrk893.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42904120",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42904120"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Gallbladder and Bile Duct Disorders",
      "subfield": "general"
    }
  ],
  "title": "Preoperative Frailty and Risk of Post-ERCP Pancreatitis in Older Adults with Choledocholithiasis.",
  "title_text": "Preoperative Frailty and Risk of Post-ERCP Pancreatitis in Older Adults with Choledocholithiasis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/3b78xq9vrk893",
  "venue": "Clinical interventions in aging",
  "versions": []
}