{
  "abstract": "A previously healthy 10-year-old boy developed febrile seizure-like episodes after an appendectomy, which were diagnosed as epilepsy despite a normal electroencephalogram. He later presented with dyspnea and palpitations and was prescribed propafenone for frequent premature ventricular complexes. The electrocardiogram showed a markedly prolonged QTc interval of 550 ms with a notched T wave in lead V2. Phenytoin and propafenone were discontinued, and propranolol was initiated, but QTc prolongation persisted. The combination of severely prolonged QTc, characteristic T-wave morphology, and absence of structural heart disease redirected the diagnosis toward a repolarization channelopathy; genetic testing confirmed long-QT syndrome type 2 due to a pathogenic KCNH2 c.1814C>T variant. β-blocker therapy was optimized, QT-prolonging triggers were avoided, and a subcutaneous implantable cardioverter-defibrillator was implanted. Cascade genetic screening identified no additional KCNH2 carriers. One variant-negative sister had frequent idiopathic right ventricular outflow tract premature ventricular complexes and was referred for catheter ablation.",
  "abstract_shown": true,
  "affiliations": [
    "Instituto Nacional Cardiovascular, INCOR-EsSalud, Lima, Peru. Instituto Nacional Cardiovascular, INCOR-EsSalud Lima Peru",
    "Unidad de arritmias, Instituto Nacional Cardiovascular, INCOR-EsSalud, Lima, Peru. Unidad de arritmias, Instituto Nacional Cardiovascular, INCOR-EsSalud Lima Peru"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Alexis Vallejos-Barrientos",
      "orcid": "0009-0009-0885-6763"
    },
    {
      "affs": [
        0
      ],
      "name": "Alessandra Centeno-Araujo",
      "orcid": "0000-0002-0820-015X"
    },
    {
      "affs": [
        1
      ],
      "name": "Richard Soto-Becerra",
      "orcid": "0000-0003-3447-061X"
    },
    {
      "affs": [
        1
      ],
      "name": "Mario Cabrera-Saldaña",
      "orcid": "0000-0001-9802-1376"
    },
    {
      "affs": [
        1
      ],
      "name": "Carolina Guevara-Caicedo",
      "orcid": "0000-0002-2240-8547"
    },
    {
      "affs": [
        1
      ],
      "name": "Ana Cecilia Gonzales-Luna",
      "orcid": "0000-0002-8575-1596"
    },
    {
      "affs": [
        1
      ],
      "name": "Marisel Payano-Rojas",
      "orcid": "0009-0002-6153-6645"
    },
    {
      "affs": [
        1
      ],
      "name": "Ángel Cueva-Parra",
      "orcid": "0000-0002-9548-4428"
    },
    {
      "affs": [
        0
      ],
      "name": "Ronal Calle-García",
      "orcid": "0009-0004-2536-1053"
    },
    {
      "affs": [
        0
      ],
      "name": "Carlos Ramos-Godoy",
      "orcid": "0009-0003-6686-352X"
    },
    {
      "affs": [
        1
      ],
      "name": "Pío Zelaya-Castro",
      "orcid": "0009-0000-4485-9173"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3be4425dpkas2.bib",
  "cited_by": 0,
  "doi": "10.47487/apcyccv.v7i3.601",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13738452/",
  "id": "3be4425dpkas2",
  "issns": [
    "2708-7212"
  ],
  "landing_url": "https://doi.org/10.47487/apcyccv.v7i3.601",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "openalex",
      "2705|Cardiac electrophysiology and arrhythmias"
    ]
  ],
  "openalex": "W7203487991",
  "pdf_url": "https://apcyccv.org.pe/index.php/apccc/article/download/601/787",
  "pmcid": "PMC13738452",
  "pmid": "42992241",
  "published": "2026-09-26",
  "publisher": "Instituto Nacional Cardiovascular - INCOR",
  "ris": "https://research.draconitic.com/paper/3be4425dpkas2.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:23:26Z",
      "native_id": "PMC13738452",
      "source": "pmc",
      "url": "https://doi.org/10.47487/apcyccv.v7i3.601"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiac electrophysiology and arrhythmias",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Neurologic presentation unmasks arrhythmogenic channelopathy: KCNH2 variant Long-QT syndrome managed with subcutaneous implantable cardioverter-defibrillator. A case report",
  "title_text": "Neurologic presentation unmasks arrhythmogenic channelopathy: KCNH2 variant Long-QT syndrome managed with subcutaneous implantable cardioverter-defibrillator. A case report",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:23:26Z",
  "url": "https://research.draconitic.com/paper/3be4425dpkas2",
  "venue": "Archivos Peruanos de Cardiología y Cirugía Cardiovascular",
  "versions": []
}