{
  "abstract": "Vitamin B6 (VB6) is an essential nutrient that must be obtained from the diet by humans and livestock, and plays an important role in response to various biotic and abiotic stresses in plants. Although the VB6 biosynthesis pathway has been uncovered in higher plants, understanding of its genetic control remains limited, and the role of VB6 in responding to cold stress is largely unknown. Here, we showed that variation in VB6 levels in rice is attributable to differential transcription of OsPDX1.2, a pyridoxal phosphate synthase, due to polymorphisms in its promoter. Natural variations in the OsPDX1.2 promoter affect the binding affinity of OsbZIP18, a transcriptional factor repressing OsPDX1.2 transcription. Loss of function in OsPDX1.2 or overexpression of OsbZIP18 significantly reduces cold tolerance in rice. Further investigation revealed that both genes affect cold tolerance by regulating VB6 and abscisic acid (ABA) biosynthesis. Moreover, the frequency of the cold‐tolerant pOsPDX1.2\n\nHap2 increases at higher latitudes, whereas the cold‐sensitive pOsPDX1.2\n\nHap1 increases at lower latitudes, indicating that natural variation in OsPDX1.2 contributes to differential cold adaptation in rice. Overall, our results reveal a regulatory pathway controlling rice VB6 accumulation and cold tolerance via the OsbZIP18–OsPDX1.2 module, providing a potential target for improving rice quality and stress tolerance.",
  "abstract_shown": true,
  "affiliations": [
    "School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication) Hainan University Sanya 572025 China",
    "Yazhouwan National Laboratory Sanya 572025 China",
    "Hainan Seed Industry Laboratory Sanya 572025 China",
    "Sanya Institute Hainan Academy of Agricultural Sciences Sanya 572025 China",
    "Max Planck Institute of Molecular Plant Physiology Potsdam‐Golm 14476 Germany",
    "Henan Key Laboratory of Rice Molecular Breeding and High Efficiency Production, College of Agronomy Henan Agricultural University Zhengzhou 450046 China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 19,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Bi Wang",
      "orcid": "0009-0002-0978-8191"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiu Yi Wang",
      "orcid": "0009-0003-4271-2057"
    },
    {
      "affs": [
        0
      ],
      "name": "Wen Jie Shi",
      "orcid": "0009-0007-7334-1825"
    },
    {
      "affs": [
        0
      ],
      "name": "Rong Hui Li",
      "orcid": "0009-0000-5308-9326"
    },
    {
      "affs": [
        0
      ],
      "name": "Xu Dong Zhang",
      "orcid": "0009-0006-2050-7695"
    },
    {
      "affs": [
        0
      ],
      "name": "Li Ping Wang",
      "orcid": "0009-0005-3750-0409"
    },
    {
      "affs": [
        0
      ],
      "name": "Shi Jia Xia",
      "orcid": "0009-0006-1486-6691"
    },
    {
      "affs": [
        0
      ],
      "name": "Kai Xi Chen",
      "orcid": "0009-0002-4217-0000"
    },
    {
      "affs": [
        1
      ],
      "name": "Jun Jie Zhou",
      "orcid": "0000-0003-1448-9348"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Yang Yang Sun",
      "orcid": "0000-0003-3232-2939"
    },
    {
      "affs": [
        0
      ],
      "name": "Jing He",
      "orcid": "0009-0008-0622-989X"
    },
    {
      "affs": [
        4
      ],
      "name": "Alisdair R. Fernie",
      "orcid": "0000-0001-9000-335X"
    },
    {
      "affs": [
        5
      ],
      "name": "Ying Chun Han",
      "orcid": "0000-0002-9320-6969"
    },
    {
      "affs": [
        5
      ],
      "name": "Jun Zhou Li",
      "orcid": "0000-0002-4122-6722"
    },
    {
      "affs": [
        1
      ],
      "name": "Yu Heng Shi",
      "orcid": "0000-0001-5714-6180"
    },
    {
      "affs": [
        0
      ],
      "name": "Xian Qing Liu",
      "orcid": "0000-0002-3659-9110"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuan Yuan Zhang",
      "orcid": "0000-0003-1325-6921"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jie Luo",
      "orcid": "0000-0002-4931-7469"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Cheng Jin",
      "orcid": "0000-0002-8755-7607"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3bfjztkmwe86q.bib",
  "cited_by": 0,
  "doi": "10.1111/jipb.70322",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13725607/",
  "id": "3bfjztkmwe86q",
  "issns": [
    "1672-9072",
    "1744-7909"
  ],
  "landing_url": "https://doi.org/10.1111/jipb.70322",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Abiotic Stress Responses"
    ],
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "1110|Plant Stress Responses and Tolerance"
    ]
  ],
  "openalex": "W7164819103",
  "pdf_url": null,
  "pmcid": "PMC13725607",
  "pmid": "42290547",
  "published": "2026-06-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3bfjztkmwe86q.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:57Z",
      "native_id": "PMC13725607",
      "source": "pmc",
      "url": "https://doi.org/10.1111/jipb.70322"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Plant Stress Responses and Tolerance",
      "subfield": "plant-biology"
    }
  ],
  "title": "Natural variation in the promoter of OsPDX1.2 enhances vitamin B6 accumulation and cold tolerance in rice",
  "title_text": "Natural variation in the promoter of OsPDX1.2 enhances vitamin B6 accumulation and cold tolerance in rice",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:48Z",
  "url": "https://research.draconitic.com/paper/3bfjztkmwe86q",
  "venue": "Journal of Integrative Plant Biology",
  "versions": []
}