{
  "abstract": "Objectives\n\nTo compare long-term outcomes of transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) in patients aged 70 to 89 years with aortic stenosis (AS).Methods\n\nIn this single-center retrospective study, 1100 patients who underwent primary TAVR (n = 599) or SAVR (n = 501) between 2008 and 2023 were included. An overlap-weighted propensity-score analysis was conducted using 36 baseline variables, including age, procedural year, frailty scale, Society of Thoracic Surgeons risk score, New York Heart Association class, history of coronary artery and cerebrovascular disease, and AS severity. The primary end point was the composite of all-cause mortality or cerebrovascular events.Results\n\nDuring long-term follow-up, the composite end point occurred more frequently after TAVR than after SAVR. In the overlap-weighted analysis, TAVR was associated with a greater risk of the composite outcome (hazard ratio [HR], 1.8; 95% CI, 1.1-3.0; P = .024), with Kaplan-Meier curves diverging early and remaining separated. All-cause mortality did not differ between the groups (HR, 1.2; 95% CI, 0.7-2.1; P = .426); however, cerebrovascular events occurred predominantly after TAVR and remained significantly more frequent after overlap weighting (HR, 15; 95% CI, 2.8-89; P = .002).Conclusions\n\nIn the overlap-weighted population of patients aged 70 to 89 years with AS, SAVR and TAVR were associated with comparable all-cause mortality; however, cerebrovascular events occurred more frequently after TAVR.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiac Surgery, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.",
    "Department of Critical Care Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.",
    "Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 21,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Rieko Kutsuzawa"
    },
    {
      "affs": [
        0
      ],
      "name": "Naonori Kawamoto"
    },
    {
      "affs": [
        1
      ],
      "name": "Kimito Minami"
    },
    {
      "affs": [
        0
      ],
      "name": "Satoshi Kainuma"
    },
    {
      "affs": [
        0
      ],
      "name": "Kizuku Yamashita"
    },
    {
      "affs": [
        0
      ],
      "name": "Kota Suzuki"
    },
    {
      "affs": [
        0
      ],
      "name": "Takashi Kakuta"
    },
    {
      "affs": [
        0
      ],
      "name": "Ayumi Ikuta"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuki Tadokoro"
    },
    {
      "affs": [
        0
      ],
      "name": "Yojiro Machii"
    },
    {
      "affs": [
        2
      ],
      "name": "Kentaro Mitsui"
    },
    {
      "affs": [
        2
      ],
      "name": "Shinichi Kurashima"
    },
    {
      "affs": [
        2
      ],
      "name": "Yuki Irie"
    },
    {
      "affs": [
        2
      ],
      "name": "Atsushi Okada"
    },
    {
      "affs": [
        2
      ],
      "name": "Kensuke Takagi"
    },
    {
      "affs": [
        2
      ],
      "name": "Makoto Amaki"
    },
    {
      "affs": [
        2
      ],
      "name": "Hideaki Kanzaki"
    },
    {
      "affs": [
        2
      ],
      "name": "Yasuhide Asaumi"
    },
    {
      "affs": [
        2
      ],
      "name": "Takeshi Kitai"
    },
    {
      "affs": [
        2
      ],
      "name": "Chisato Izumi"
    },
    {
      "affs": [
        0
      ],
      "name": "Satsuki Fukushima"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3bj60tpae3fd5.bib",
  "cited_by": 0,
  "doi": "10.1016/j.xjon.2026.101972",
  "fulltext_url": "https://europepmc.org/articles/PMC13711200",
  "id": "3bj60tpae3fd5",
  "issns": [
    "2666-2736"
  ],
  "landing_url": "https://europepmc.org/article/MED/42948429",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Adult: Aortic Valve"
    ],
    [
      "openalex",
      "2705|Cardiac Valve Diseases and Treatments"
    ]
  ],
  "openalex": "W7170700838",
  "pdf_url": "https://europepmc.org/articles/PMC13711200?pdf=render",
  "pmcid": "PMC13711200",
  "pmid": "42948429",
  "published": "2026-07-24",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/3bj60tpae3fd5.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:36Z",
      "native_id": "MED:42948429",
      "source": "europepmc",
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    },
    {
      "first_seen": "2026-10-31T12:22:01Z",
      "native_id": "PMC13711200",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.xjon.2026.101972"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiac Valve Diseases and Treatments",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Long-term outcomes of transcatheter versus surgical aortic valve replacement in patients aged 70 years and older: An overlap-weighted analysis.",
  "title_text": "Long-term outcomes of transcatheter versus surgical aortic valve replacement in patients aged 70 years and older: An overlap-weighted analysis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:22:01Z",
  "url": "https://research.draconitic.com/paper/3bj60tpae3fd5",
  "venue": "JTCVS open",
  "versions": []
}