{
  "abstract": "BackgroundTo investigate the diagnostic value of a computed tomography (CT)-based multimodal 2.5-dimensional (2.5D) deep learning model for differentiating Talaromyces marneffei (TSM) from pulmonary tuberculosis (PTB) in patients with human immunodeficiency virus infection/acquired immunodeficiency syndrome (HIV/AIDS).MethodsA total of 380 HIV/AIDS patients with pulmonary infections who were admitted to the Fourth People’s Hospital of Nanning from January 2018 to August 2025 were retrospectively enrolled, including 203 patients with PTB, 177 with TSM. The cohort was randomly divided into a training set and a test set at a ratio of 7:3. A clinical model, a radiomics model, and a 2.5D deep learning model were constructed separately.ResultsIn the clinical feature model, Random Forest achieved the optimal performance, with a test set AUC of 0.856. In the radiomics model, XGBoost attained the highest AUC of 0.866. In the 2.5D deep learning model, ResNet18 performed best at the slice level with an AUC of 0.865, and the patient-level support vector machine (SVM) model based on MIL achieved an AUC of 0.885. The multimodal combined model integrating clinical, radiomics, and deep learning features achieved the highest AUC of 0.931 and a specificity of 0.981. It significantly outperformed the clinical model (P = 0.020) and the radiomics model (P = 0.008), but the improvement over DL25D was not statistically significant (ΔAUC = 0.046; P = 0.116). The high specificity of the combined model should be interpreted alongside its sensitivity (0.717) and the selected decision threshold.ConclusionThe CT-based multimodal 2.5D deep learning model effectively integrates clinical indicators, radiomics features, and deep learning representations, and substantially improves the differentiation of TSM from PTB in HIV/AIDS patients.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Tuberculosis, The Fourth People’s Hospital of Nanning, Nanning, Guangxi, China",
    "Clinical Medical School, Guangxi Medical University, Nanning, Guangxi, China",
    "Department of Radiology, The Fourth People’s Hospital of Nanning, Nanning, Guangxi, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
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        0
      ],
      "name": "Chang Song"
    },
    {
      "affs": [
        1
      ],
      "name": "Chang Song"
    },
    {
      "affs": [
        0
      ],
      "name": "Chun-Yan Zhao"
    },
    {
      "affs": [
        1
      ],
      "name": "Chun-Yan Zhao"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiao-Shi Lin"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhen-Tao Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xue-Wen Huang"
    },
    {
      "affs": [
        1
      ],
      "name": "Xue-Wen Huang"
    },
    {
      "affs": [
        2
      ],
      "name": "Shu-Lin Song"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhou-Hua Xie"
    },
    {
      "affs": [
        0
      ],
      "name": "Qing-Dong Zhu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3c7vwk87nf8c9.bib",
  "cited_by": 0,
  "doi": "10.3389/fcimb.2026.1927286",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fcimb.2026.1927286/full",
  "id": "3c7vwk87nf8c9",
  "issns": [
    "2235-2988"
  ],
  "landing_url": "https://doi.org/10.3389/fcimb.2026.1927286",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QR1-502"
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      "openalex",
      "2741|Radiomics and Machine Learning in Medical Imaging"
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  "openalex": "W7223377114",
  "pdf_url": "https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1927286/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "Frontiers Media S.A.",
  "ris": "https://research.draconitic.com/paper/3c7vwk87nf8c9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:13Z",
      "native_id": "f865773a91254164833980029ce3f386",
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      "url": "https://doi.org/10.3389/fcimb.2026.1927286"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Radiomics and Machine Learning in Medical Imaging",
      "subfield": "imaging"
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  ],
  "title": "Differential diagnosis of pulmonary Talaromyces marneffei infection and pulmonary tuberculosis in HIV/AIDS patients using a CT-based multimodal 2.5D deep learning approach",
  "title_text": "Differential diagnosis of pulmonary Talaromyces marneffei infection and pulmonary tuberculosis in HIV/AIDS patients using a CT-based multimodal 2.5D deep learning approach",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:13Z",
  "url": "https://research.draconitic.com/paper/3c7vwk87nf8c9",
  "venue": "Frontiers in Cellular and Infection Microbiology",
  "versions": []
}