{
  "abstract": "GBA1 variants increase neuropsychiatric vulnerability in Parkinson’s disease (PD). In a multicenter cohort of 234 PD patients (78 GBA-PD, 156 nonGBA-PD), we investigated how GBA1 genotype and sex relate to depression. REM sleep behavior disorder was associated with depression in GBA-PD, while sex, cognition, and motor complications were predictors in nonGBA-PD. Depressive symptoms were more severe and progressed faster in GBA-PD, supporting specific monitoring of this genetic subgroup.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy",
    "IRCCS Mondino Foundation, Pavia, Italy",
    "Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy",
    "SC Neurologia 2U, AOU Città della Salute e della Scienza, Turin, Italy",
    "Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy",
    "IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy",
    "Department of Biomedical and NeuroMotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy",
    "Department of Psychology, University of Campania Luigi Vanvitelli, Caserta, Italy",
    "Department of Molecular Medicine, University of Pavia, Pavia, Italy"
  ],
  "article_type": "brief report",
  "arxiv": null,
  "author_total": 21,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Pierfrancesco Mitrotti"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Micol Avenali"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Carlo Alberto Artusi"
    },
    {
      "affs": [
        4
      ],
      "name": "Rosa De Micco"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Giulia Giannini"
    },
    {
      "affs": [
        1
      ],
      "name": "Rosaria Calabrese"
    },
    {
      "affs": [
        0
      ],
      "name": "Luca Gallo"
    },
    {
      "affs": [
        1
      ],
      "name": "Caterina Galandra"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Claudia Ledda"
    },
    {
      "affs": [
        2
      ],
      "name": "Alice Mascia"
    },
    {
      "affs": [
        4,
        7
      ],
      "name": "Mattia Siciliano"
    },
    {
      "affs": [
        4
      ],
      "name": "Francesco Pagliuca"
    },
    {
      "affs": [
        5
      ],
      "name": "Luisa Sambati"
    },
    {
      "affs": [
        4,
        7
      ],
      "name": "Valeria Sant’Elia"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Gianfranco Vornetti"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Giovanna Calandra-Buonaura"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Leonardo Lopiano"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Raffaele Lodi"
    },
    {
      "affs": [
        4
      ],
      "name": "Alessandro Tessitore"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Marco Bozzali"
    },
    {
      "affs": [
        1,
        8
      ],
      "name": "Enza Maria Valente"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3cgd5hhw83wkb.bib",
  "cited_by": 0,
  "doi": "10.1038/s41531-026-01460-2",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13724703/",
  "id": "3cgd5hhw83wkb",
  "issns": [
    "2373-8057"
  ],
  "landing_url": "https://doi.org/10.1038/s41531-026-01460-2",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Brief Communication"
    ],
    [
      "openalex",
      "2728|Parkinson's Disease Mechanisms and Treatments"
    ]
  ],
  "openalex": "W7167675840",
  "pdf_url": "https://www.nature.com/articles/s41531-026-01460-2_reference.pdf",
  "pmcid": "PMC13724703",
  "pmid": "42420305",
  "published": "2026-07-08",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/3cgd5hhw83wkb.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:14Z",
      "native_id": "PMC13724703",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41531-026-01460-2"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Parkinson's Disease Mechanisms and Treatments",
      "subfield": "neurology"
    }
  ],
  "title": "Association of GBA1 status and sex with depression severity and progression in Parkinson’s disease",
  "title_text": "Association of GBA1 status and sex with depression severity and progression in Parkinson’s disease",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:07Z",
  "url": "https://research.draconitic.com/paper/3cgd5hhw83wkb",
  "venue": "NPJ Parkinson's Disease",
  "versions": []
}