{
  "abstract": "TAPESTRY (https://tapestry.rokitalab.com) is a database and web application for exploring recurrent tumor-enriched splice junctions (TEJs) in pediatric brain tumors, cancers that carry few protein-coding mutations and therefore few mutation-derived neoantigens. However, TEJs represent a much larger source of neoantigens as potential therapeutic targets in these tumors. TAPESTRY catalogs 45,430 recurrent TEJs across 19 histologies, identified in 1,962 RNA-seq specimens (including 1,272 independent primary tumors) from the Pediatric Brain Tumor Atlas and compared to four normal brain reference cohorts comprising adult, pediatric, developmental and cell-type-resolved tissue. Each junction is classified as tumor-specific or oncofetal; annotated for splice-event type, coding consequence, novelty relative to GENCODE v39 and overlap with Pfam and UniProt protein domains; and scored for recurrence within each histology. Users can search by gene or splicing event and filter results by histology, junction class, and annotation. Users can also generate gene-level expression heatmaps across cohorts, junction-level expression boxplots, and transcript and exon diagrams, and download all tables and figures. A documented REST API supports programmatic access, and all source code is openly available. By making tumor-selective and developmentally reactivated splicing events searchable and interpretable, TAPESTRY supports the prioritization of splice-derived targets for antibody-based, cell-based and vaccine immunotherapies in pediatric brain and central nervous system tumors.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": "2610.31816",
  "author_total": 7,
  "authors": [
    {
      "name": "Patricia J. Sullivan"
    },
    {
      "name": "Ryan J. Corbett"
    },
    {
      "name": "Chao Di"
    },
    {
      "name": "Alex Sickler"
    },
    {
      "name": "Aylar Babaei"
    },
    {
      "name": "Meghali Goswami"
    },
    {
      "name": "Jo Lynne Rokita"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3cnetae5wesxx.bib",
  "cited_by": 0,
  "doi": "10.48550/arxiv.2610.31816",
  "fulltext_url": null,
  "id": "3cnetae5wesxx",
  "issns": [],
  "landing_url": "https://arxiv.org/abs/2610.31816",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": "CC0-1.0",
  "native_subjects": [
    [
      "arxiv",
      "q-bio.GN"
    ],
    [
      "openalex",
      "1312|RNA Research and Splicing"
    ]
  ],
  "openalex": "W7223652665",
  "pdf_url": "https://arxiv.org/pdf/2610.31816",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3cnetae5wesxx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:35:20Z",
      "native_id": "2610.31816",
      "source": "arxiv",
      "url": "https://arxiv.org/abs/2610.31816"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "arxiv:q-bio.GN",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "TAPESTRY: an interactive resource for exploring tumor-enriched splice junctions in pediatric brain tumors",
  "title_text": "TAPESTRY: an interactive resource for exploring tumor-enriched splice junctions in pediatric brain tumors",
  "type": "preprint",
  "updated_at": "2026-10-30T12:35:20Z",
  "url": "https://research.draconitic.com/paper/3cnetae5wesxx",
  "venue": "arXiv",
  "versions": []
}