{
  "abstract": "Patients with Beta (β)-thalassemia require regular blood transfusions. The presence of red blood cell (RBC) alloantibodies can complicate transfusion treatment. This can lead to delays in obtaining compatible blood, and in some case temporarily rendering blood transfusion impossible. We present a case demonstrating the successful adjunctive management of a patient with transfusion-dependent β-thalassemia complicated by RBC alloimmunization using a novel therapeutic agent. A 32-year-old Thai female with homozygous β-thalassemia was admitted to the Hospital of Tropical Diseases, Bangkok, with symptoms of anemia. Cross-matching studies revealed the presence of alloantibodies at admission. Treatment with luspatercept, a novel erythroid maturation agent, resulted in an increase in hemoglobin levels and an extension of the transfusion interval. The patient received four doses of luspatercept while awaiting antigen-compatible RBC units. Although luspatercept had no direct effect on RBC alloimmunization or existing alloantibodies, its ability to reduce transfusion requirements may decrease the need for subsequent RBC transfusions, and thereby reduce further antigen exposure. This may be particularly beneficial in patients with complex alloantibody profiles. This case highlights the potential role of luspatercept as adjunctive supportive therapy to delay transfusions requirements in patients with transfusion-dependent β-thalassemia complicated by RBC alloimmunization.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand",
    "Division of Hematology, Department of Medicine, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand",
    "Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand",
    "Samitivej Srinakarin Hospital, Bangkok, Thailand"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Fariha Fairouz"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Supat Chamnanchanunt",
      "orcid": "0000-0003-1956-1097"
    },
    {
      "affs": [
        0
      ],
      "name": "Vipa Thanachartwet"
    },
    {
      "affs": [
        0
      ],
      "name": "Varunee Desakorn"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Suthat Fucharoen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3czhd5ze526r8.bib",
  "cited_by": 0,
  "doi": "10.1177/20406207261491921",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13724923/",
  "id": "3czhd5ze526r8",
  "issns": [
    "2040-6207",
    "2040-6215"
  ],
  "landing_url": "https://doi.org/10.1177/20406207261491921",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "openalex",
      "2716|Hemoglobinopathies and Related Disorders"
    ]
  ],
  "openalex": "W7213616723",
  "pdf_url": "https://europepmc.org/articles/PMC13724923?pdf=render",
  "pmcid": "PMC13724923",
  "pmid": "42973742",
  "published": "2026-09-18",
  "publisher": "SAGE Publications",
  "ris": "https://research.draconitic.com/paper/3czhd5ze526r8.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:24Z",
      "native_id": "PMC13724923",
      "source": "pmc",
      "url": "https://doi.org/10.1177/20406207261491921"
    },
    {
      "first_seen": "2026-11-04T15:20:49Z",
      "native_id": "MED:42973742",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42973742"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Hemoglobinopathies and Related Disorders",
      "subfield": "human-genetics"
    }
  ],
  "title": "Impact of luspatercept in beta-thalassemia major with alloimmunization: A case report",
  "title_text": "Impact of luspatercept in beta-thalassemia major with alloimmunization: A case report",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:18Z",
  "url": "https://research.draconitic.com/paper/3czhd5ze526r8",
  "venue": "Therapeutic Advances in Hematology",
  "versions": []
}