{
  "abstract": "Severe immune-related adverse events (irAE) in cancer patients receiving immune checkpoint inhibitors (ICI) require treatment interruption and immunosuppression. Based on prior preclinical data, in this prospective, single arm, non-randomized phase-Ib/II clinical trial we test the activity of Extracorporeal Photopheresis (ECP) against steroid-refractory irAEs in 30 patients (EudraCT-No.:2021-002073-26). The primary endpoint is the evaluation of the safety of ECP treatment for patients with ICI-induced irAEs. The study meets its pre-specified primary endpoint of less than 50% of patients developing ECP-related severe adverse events (SAE). No ECP-related SAE is observed and ECP-related AEs are reported in 20% (6/30) of patients. Overall response rate for all irAEs is 96.3% (CI 81.0–99.91). Colitis-, hepatitis- and dermatitis-specific response rates are 100% (13/13), 86.7% (13/15) and 100% (3/3), respectively. Secondary endpoints include the assessment of response rate of irAE and overall survival. ECP therapy is associated with reduced granzyme-A/B/K, T-bet, interferon-γ and TNF in peripheral T cells and pro-inflammatory gene-expression in the intestinal tract. The 12-month overall survival rate is 84.3% (CI 63.4%-93.8%). Response correlates with a decrease in inflammatory gene expression in the intestinal tract. These results suggest that ECP is a safe treatment option for SR-irAEs and warrant further investigation in subsequent randomized clinical trials.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research support, non u.s. gov't",
  "arxiv": null,
  "author_total": 46,
  "authors": [
    {
      "name": "Roxane Riemer"
    },
    {
      "name": "Lukas M. Braun",
      "orcid": "0000-0003-0770-4994"
    },
    {
      "name": "Sophie Giesler",
      "orcid": "0000-0002-8146-2199"
    },
    {
      "name": "David Rafei-Shamsabadi",
      "orcid": "0000-0002-7850-3199"
    },
    {
      "name": "Sebastian Haferkamp"
    },
    {
      "name": "Alina Hartmann"
    },
    {
      "name": "Wolfgang Melchinger"
    },
    {
      "name": "Matthias Weiss"
    },
    {
      "name": "Stefanie Birth"
    },
    {
      "name": "Ulrike Philipp"
    },
    {
      "name": "Inga Gebhard"
    },
    {
      "name": "Carsten Schwänen"
    },
    {
      "name": "James A. Hutchinson",
      "orcid": "0000-0002-1199-4210"
    },
    {
      "name": "Nikolaos Karantzelis"
    },
    {
      "name": "Till Wallrabenstein",
      "orcid": "0000-0002-6672-3135"
    },
    {
      "name": "Theresa Lowinus"
    },
    {
      "name": "Niklas Brehm"
    },
    {
      "name": "Justyna Rawluk"
    },
    {
      "name": "Dietmar Pfeifer"
    },
    {
      "name": "Natascha Osswald",
      "orcid": "0009-0003-8095-5287"
    },
    {
      "name": "Peter Bronsert",
      "orcid": "0000-0001-8558-0347"
    },
    {
      "name": "Manuel Rogg",
      "orcid": "0000-0002-6658-9159"
    },
    {
      "name": "Grigor Andreev",
      "orcid": "0009-0008-3808-8331"
    },
    {
      "name": "Melanie Boerries",
      "orcid": "0000-0002-3670-0602"
    },
    {
      "name": "Maximilian Lammer",
      "orcid": "0009-0002-7306-5457"
    },
    {
      "name": "Van Anh Nguyen"
    },
    {
      "name": "Matthias Schmuth"
    },
    {
      "name": "Natalie Köhler",
      "orcid": "0000-0002-7502-0431"
    },
    {
      "name": "Justus Duyster",
      "orcid": "0000-0001-7325-7753"
    },
    {
      "name": "Gabriele Ihorst",
      "orcid": "0000-0002-8091-1589"
    },
    {
      "name": "Philip Keye",
      "orcid": "0000-0001-8307-5267"
    },
    {
      "name": "Susana Minguet",
      "orcid": "0000-0001-8211-5538"
    },
    {
      "name": "Dirk Schadendorf",
      "orcid": "0000-0003-3524-7858"
    },
    {
      "name": "Selma Ugurel",
      "orcid": "0000-0002-9384-6704"
    },
    {
      "name": "Robert Thimme",
      "orcid": "0000-0003-1417-4135"
    },
    {
      "name": "Peter Hasselblatt"
    },
    {
      "name": "Erika L. Pearce",
      "orcid": "0000-0001-5592-5439"
    },
    {
      "name": "Burkhard Becher",
      "orcid": "0000-0002-1541-7867"
    },
    {
      "name": "Carolin Funke-Lorenz"
    },
    {
      "name": "Florian Scherer",
      "orcid": "0000-0001-9635-5487"
    },
    {
      "name": "Bertram Bengsch",
      "orcid": "0000-0003-2552-740X"
    },
    {
      "name": "Christoph Schell"
    },
    {
      "name": "Jan-Malte Placke"
    },
    {
      "name": "Frank Meiss",
      "orcid": "0000-0002-4044-9094"
    },
    {
      "name": "Petya Apostolova",
      "orcid": "0000-0002-3856-5109"
    },
    {
      "name": "Robert Zeiser",
      "orcid": "0000-0001-6565-3393"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3djb2s9v4cy4x.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-78897-9",
  "fulltext_url": "https://europepmc.org/articles/PMC13694692",
  "id": "3djb2s9v4cy4x",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-78897-9",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Cancer Immunotherapy and Biomarkers"
    ]
  ],
  "openalex": "W7223336310",
  "pdf_url": "https://www.nature.com/articles/s41467-026-78897-9.pdf",
  "pmcid": "PMC13694692",
  "pmid": "42919851",
  "published": "2026-10-23",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/3djb2s9v4cy4x.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:39Z",
      "native_id": "10.1038/s41467-026-78897-9",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-78897-9"
    },
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42919851",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42919851"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cancer Immunotherapy and Biomarkers",
      "subfield": "oncology"
    }
  ],
  "title": "Extracorporeal photopheresis for the treatment of steroid-refractory immune related adverse events from immune checkpoint inhibitor therapy: a multi-center phase Ib/II clinical trial",
  "title_text": "Extracorporeal photopheresis for the treatment of steroid-refractory immune related adverse events from immune checkpoint inhibitor therapy: a multi-center phase Ib/II clinical trial",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:33Z",
  "url": "https://research.draconitic.com/paper/3djb2s9v4cy4x",
  "venue": "Nature Communications",
  "versions": []
}