{
  "abstract": "Altered extracellular biomechanical forces are increasingly implicated in a wide range of pathologies. However, the specific role of extracellular matrix stiffness in the pathogenesis of dental caries remains unclear. Although exosomes have been shown to regulate cell fate, it is still poorly understood how their biological journeys from biogenesis to secretion are affected by matrix stiffness. Here we find that matrix stiffness can enhance exosome release, thereby promoting odontogenic differentiation of dental pulp stem cells (DPSCs). Mechanistically, matrix stiffness promotes exosome release by modulating membrane curvature through Baiap2, which is tightly regulated by the stiffness‐activated PI3K‐AKT signaling pathway. Moreover, the release of exosomes was found to depend on mechanosensitive motor protein kinesin‐1 and its regulation of vesicular transport. Taken together, our results demonstrate that matrix stiffness plays an essential role in odontogenic differentiation of DPSCs by modulating exosome release. Our findings prove that the mechanosensitive process may play an underappreciated role in regulating exosome secretion and odontogenic differentiation in deep caries.",
  "abstract_shown": true,
  "affiliations": [
    "Key Laboratory of Shaanxi Province For Craniofacial Precision Medicine Research, College of Stomatology Xi'an Jiaotong University Xi'an China",
    "Clinical Research Center of Shaanxi Province For Dental and Maxillofacial Diseases, College of Stomatology Xi'an Jiaotong University Xi'an China",
    "College of Stomatology Xi'an Jiaotong University Xi'an China",
    "School of Life Science and Technology The Key Laboratory of Biomedical Information Engineering of the Ministry of Education Xi'an Jiaotong University Xi'an China",
    "Bioinspired Engineering and Biomechanics Center (BEBC) Xi'an Jiaotong University Xi'an China",
    "Department of Cell Biology and Genetics School of Basic Medical Sciences Xi'an Jiaotong University Xi'an Shaanxi China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Bilun Jin",
      "orcid": "0009-0002-4980-8476"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Shaojie Dong",
      "orcid": "0000-0001-6021-3620"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yue Jia",
      "orcid": "0009-0003-5434-7333"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Zhao Xu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Peiqi Liu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Zhaojing Ding"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yuxin Liao"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Rui Zou",
      "orcid": "0000-0003-1214-9606"
    },
    {
      "affs": [
        5
      ],
      "name": "Jinsong Hu",
      "orcid": "0000-0003-0565-4567"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Bo Cheng"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Lin Niu",
      "orcid": "0000-0002-3992-1240"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3dpfv2dw62wdn.bib",
  "cited_by": 0,
  "doi": "10.1002/advs.76908",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13460413/",
  "id": "3dpfv2dw62wdn",
  "issns": [
    "2198-3844"
  ],
  "landing_url": "https://doi.org/10.1002/advs.76908",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "1312|Extracellular vesicles in disease"
    ]
  ],
  "openalex": "W7202215819",
  "pdf_url": null,
  "pmcid": "PMC13460413",
  "pmid": "42579569",
  "published": "2026-08-11",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/3dpfv2dw62wdn.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:23:43Z",
      "native_id": "PMC13460413",
      "source": "pmc",
      "url": "https://doi.org/10.1002/advs.76908"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Extracellular vesicles in disease",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Matrix Stiffness Enhances Odontogenic Differentiation of DPSCs through Membrane Curvature Protein Baiap2‐Modulated Exosome Release",
  "title_text": "Matrix Stiffness Enhances Odontogenic Differentiation of DPSCs through Membrane Curvature Protein Baiap2‐Modulated Exosome Release",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:20:51Z",
  "url": "https://research.draconitic.com/paper/3dpfv2dw62wdn",
  "venue": "Advanced Science",
  "versions": []
}