{
  "abstract": "Autism spectrum disorder (ASD) is associated with differences in social interaction, including alterations in gaze behavior and interpersonal distance. Although most assessments of ASD remain individual-centric, emerging human studies indicate that social difficulties may arise from atypical dyadic coordination rather than from reduced social interest alone. We examined dyadic coordination in a non-human primate model of ASD, focusing on gaze and inter-individual distance during minimally constrained first encounters between prenatal valproic acid-exposed marmosets (VPA) and unexposed conspecifics (UE). Markerless pose estimation quantified frame-by-frame gaze direction and spacing, comparing VPA–UE with UE–UE dyads. VPA–UE pairs exhibited a higher proportion of mutual-gaze events than UE–UE pairs. VPA individuals showed more rapid looks in response to the partner’s gaze, yet exhibited a lower proportion of one-sided looking events. VPA–UE dyads maintained shorter inter-individual distances than UE–UE dyads, and closer spacing was associated with decreased stability of mutual gaze. These findings reveal a dyadic coordination pattern in VPA–UE pairs, with rapid responsiveness coupled with a distance-dependent reduction in time spent in mutual gaze, paralleling features reported in human ASD. Our dyad-centric, markerless framework yields ecologically grounded readouts and potential intervention targets that leverage intact social responsiveness while accommodating altered spatial coordination.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Madoka Nakamura"
    },
    {
      "name": "Tomoko Sato"
    },
    {
      "name": "Tohru Kurotani"
    },
    {
      "name": "Kazuhisa Sakai"
    },
    {
      "name": "Anna Hadjiev"
    },
    {
      "name": "Shuntaro Sasai"
    },
    {
      "name": "Koki Mimura"
    },
    {
      "name": "Nobuyuki Kawai"
    },
    {
      "name": "Tsuyoshi Shimmura"
    },
    {
      "name": "Noritaka Ichinohe"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3dqgz7b2r2hjq.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-76138-z",
  "fulltext_url": null,
  "id": "3dqgz7b2r2hjq",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://www.nature.com/articles/s41598-026-76138-z",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2805|Autism Spectrum Disorder Research"
    ]
  ],
  "openalex": "W7224079010",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/3dqgz7b2r2hjq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:36Z",
      "native_id": "10.1038/s41598-026-76138-z",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41598-026-76138-z"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2805|Autism Spectrum Disorder Research",
      "subfield": "neuroscience"
    }
  ],
  "title": "Heightened gaze responsiveness and mutual gaze instability at close distances characterize dyadic coordination in a marmoset model of autism",
  "title_text": "Heightened gaze responsiveness and mutual gaze instability at close distances characterize dyadic coordination in a marmoset model of autism",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:36Z",
  "url": "https://research.draconitic.com/paper/3dqgz7b2r2hjq",
  "venue": "Scientific Reports",
  "versions": []
}