{
  "abstract": "Background/Objectives: Exercise may alter resting circulating interleukin-6 (IL-6) in people with overweight or obesity, but comparative effects and dose relationships remain uncertain. Methods: Five databases were searched from inception to 1 March 2026. A frequentist multivariate random-effects network model estimated Hedges g for between-arm differences in IL-6 change using a common within-study pooled change-score SD. Shared-arm sampling covariance and correlated random effects were modeled explicitly. Positive values indicated greater IL-6 reduction. Adult-only exploratory dose models used assigned MET-min/week. Results: The final network comprised 38 randomized reports, 91 arms, with retained arm sample sizes summing to 1518. AE versus control was 0.70 (0.32 to 1.07); CE was 0.36 (−0.11 to 0.82); HIIT was 0.42 (−0.20 to 1.03); and RT was −0.19 (−0.76 to 0.37) (95% confidence intervals). AE versus CE was 0.34 (95% CI −0.19 to 0.87). Heterogeneity was substantial (τ = 0.826; τ2 = 0.683), and all prediction intervals included no effect. Adult dose models favored linear functions; no stable interior optimum or effective-dose threshold was supported. Conclusions: AE had the clearest average estimate versus control, while CE, HIIT, and RT remained uncertain. The evidence was of low or very low certainty. Across-trial dose associations do not establish a causal exercise prescription. Inconsistent reporting of sampling conditions and adherence further limits interpretation.",
  "abstract_shown": true,
  "affiliations": [
    "School of Wushu, Wuhan Sports University, Wuhan 430079, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Fengrui Shi",
      "orcid": "0009-0007-1251-6062"
    },
    {
      "affs": [
        0
      ],
      "name": "Hong Wang",
      "orcid": "0000-0001-9385-0087"
    },
    {
      "affs": [
        0
      ],
      "name": "Junru Zeng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3dvz5wd7qtvta.bib",
  "cited_by": 0,
  "doi": "10.3390/metabo16110843",
  "fulltext_url": null,
  "id": "3dvz5wd7qtvta",
  "issns": [
    "2218-1989"
  ],
  "landing_url": "https://www.mdpi.com/2218-1989/16/11/843",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/3dvz5wd7qtvta.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:19Z",
      "native_id": "10.3390/metabo16110843",
      "source": "crossref",
      "url": "https://www.mdpi.com/2218-1989/16/11/843"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "issn:2218-1989",
      "subfield": "proteomics-metabolomics"
    }
  ],
  "title": "Comparative Effects and Dose–Response Relationships of Exercise Modalities on Resting Circulating Interleukin-6 in People with Overweight or Obesity: A Systematic Review and Dose–Response Network Meta-Analysis",
  "title_text": "Comparative Effects and Dose–Response Relationships of Exercise Modalities on Resting Circulating Interleukin-6 in People with Overweight or Obesity: A Systematic Review and Dose–Response Network Meta-Analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T00:21:15Z",
  "url": "https://research.draconitic.com/paper/3dvz5wd7qtvta",
  "venue": "Metabolites",
  "versions": []
}