{
  "abstract": "This work compared the radiobiological responses of SAS oral squamous cell carcinoma cells and MCF-7 breast cancer cells following accelerator-based boron neutron capture therapy (BNCT). Neutrons were generated by bombarding a lithium target with proton beams, followed by moderation to obtain sufficient thermal neutrons for BNCT irradiation. Boronophenylalanine (BPA) was used as the boron delivery agent. BNCT-induced biological responses were evaluated by gamma-H2AX immunofluorescence staining, cell-cycle analysis, apoptosis analysis, and clonogenic survival assays. BNCT induced marked gamma-H2AX foci formation in both cell lines, indicating DNA damage-associated responses after irradiation. The two cell lines further showed distinct post-irradiation outcomes. SAS cells exhibited stronger clonogenic suppression and prominent G2/M accumulation, whereas MCF-7 cells showed sustained G0/G1 accumulation and delayed apoptosis. These results suggest that BNCT sensitivity is determined by both boron accumulation and cell-line-specific biological characteristics. This work provides experimental evidence highlighting the importance of tumor-dependent cellular responses in understanding and optimizing BNCT efficacy.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": "2609.05931",
  "author_total": 7,
  "authors": [
    {
      "name": "Yuxiang Zhao"
    },
    {
      "name": "Zhao Sun"
    },
    {
      "name": "Changming Wang"
    },
    {
      "name": "Jianghao Lai"
    },
    {
      "name": "Jie Zhou"
    },
    {
      "name": "Zhencen He"
    },
    {
      "name": "Zhimin Hu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3e1hjrw0yk74p.bib",
  "cited_by": 0,
  "doi": "10.48550/arxiv.2609.05931",
  "fulltext_url": null,
  "id": "3e1hjrw0yk74p",
  "issns": [],
  "landing_url": "https://arxiv.org/abs/2609.05931",
  "language": null,
  "licence": "LicenseRef-arXiv-nonexclusive-1.0",
  "licence_label": "arXiv licence",
  "licence_source": "article",
  "licence_url": "http://arxiv.org/licenses/nonexclusive-distrib/1.0/",
  "metadata_licence": "CC0-1.0",
  "native_subjects": [
    [
      "arxiv",
      "physics.med-ph"
    ],
    [
      "openalex",
      "2741|Boron Compounds in Chemistry"
    ]
  ],
  "openalex": "W7212042584",
  "pdf_url": "https://arxiv.org/pdf/2609.05931",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3e1hjrw0yk74p.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:48Z",
      "native_id": "2609.05931",
      "source": "arxiv",
      "url": "https://arxiv.org/abs/2609.05931"
    }
  ],
  "subjects": [
    {
      "field": "physics",
      "origin": "arxiv:physics.med-ph",
      "subfield": "biological-medical"
    }
  ],
  "title": "Distinct Radiobiological Responses to BNCT in SAS Oral Squamous Cell Carcinoma and MCF-7 Breast Cancer Cells",
  "title_text": "Distinct Radiobiological Responses to BNCT in SAS Oral Squamous Cell Carcinoma and MCF-7 Breast Cancer Cells",
  "type": "preprint",
  "updated_at": "2026-10-30T12:19:48Z",
  "url": "https://research.draconitic.com/paper/3e1hjrw0yk74p",
  "venue": "arXiv",
  "versions": []
}