{
  "abstract": "Chronic kidney disease (CKD) is commonly associated with vascular injury. To date, efficient tools for assessing microcirculatory changes in non-dialysis CKD patients remain limited. We conducted a retrospectively registered study to employed nailfold capillaroscopy as a non-invasive method to evaluate peripheral microcirculation in CKD. A total of 104 participants were enrolled, including 63 patients with non-dialysis CKD patients (CKD group) and 41 healthy controls (control group). Renal function assessment and nailfold microcirculation examinations were performed for all participants. We analyzed 20 microcirculatory parameters and further explored their associations with serum creatinine (Scr), blood urea nitrogen (BUN), cystatin C, estimated glomerular filtration rate (eGFR), CKD stage, and hemoglobin (Hb) within the CKD group. Results showed that serum creatinine, cystatin C, and CKD stage were independently and positively associated with the capillary number integral, whereas eGFR and hemoglobin were independently and negatively associated with the capillary number integral. In addition, serum creatinine, cystatin C, and CKD stage were independently and negatively associated with the subpapillary venular plexus integral, while eGFR was independently and positively associated with the subpapillary venular plexus integral. In summary, our findings suggest that several key renal function parameters are independently associated with capillary number integral and subpapillary venular plexus integral. These findings indicate that renal dysfunction may be associated with reduced capillary number and impaired subpapillary venous plexus relaxation in patients with non-dialysis CKD.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Nephrology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China",
    "Clinical Research Center for Kidney Disease Xuzhou Medical University, Xuzhou, China",
    "Department of Nephrology, Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, China",
    "Department of Internal Medicine and Diagnostics, Xuzhou Medical University, Xuzhou, China"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shulin Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Ying Liu"
    },
    {
      "affs": [
        2
      ],
      "name": "Han Yan"
    },
    {
      "affs": [
        3
      ],
      "name": "Xinglei Zhou"
    },
    {
      "name": "Qi Liu"
    },
    {
      "name": "Yousuf Abdulkarim Waheed"
    },
    {
      "name": "Disheng Wang"
    },
    {
      "name": "Dong Sun"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3e9x3fwfbjhg3.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0359419",
  "fulltext_url": null,
  "id": "3e9x3fwfbjhg3",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0359419",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2727|Chronic Kidney Disease and Diabetes"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Body fluids/Blood"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Body fluids/Blood/Blood flow"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Cardiovascular anatomy/Blood vessels/Capillaries"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Renal system"
    ],
    [
      "plos",
      "/Biology and life sciences/Physiology/Body fluids/Blood"
    ],
    [
      "plos",
      "/Biology and life sciences/Physiology/Body fluids/Blood/Blood flow"
    ],
    [
      "plos",
      "/Biology and life sciences/Physiology/Cardiovascular physiology/Blood circulation/Microcirculation"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Body fluids/Blood"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Body fluids/Blood/Blood flow"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Cardiovascular anatomy/Blood vessels/Capillaries"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Renal system"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Signs and symptoms/Hemorrhage"
    ],
    [
      "plos",
      "/Medicine and health sciences/Nephrology/Renal diseases/Chronic kidney disease"
    ],
    [
      "plos",
      "/Medicine and health sciences/Vascular medicine/Blood pressure"
    ],
    [
      "plos",
      "/Medicine and health sciences/Vascular medicine/Hemorrhage"
    ]
  ],
  "openalex": "W7214944869",
  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0359419&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-30",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/3e9x3fwfbjhg3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:37Z",
      "native_id": "10.1371/journal.pone.0359419",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0359419"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "plos:anatomy",
      "subfield": "physiology"
    }
  ],
  "title": "Assessment of nailfold microcirculation in non-dialysis CKD: Capillaroscopic indicators correlated with renal dysfunction",
  "title_text": "Assessment of nailfold microcirculation in non-dialysis CKD: Capillaroscopic indicators correlated with renal dysfunction",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:37Z",
  "url": "https://research.draconitic.com/paper/3e9x3fwfbjhg3",
  "venue": "PLOS One",
  "versions": []
}