{
  "abstract": "Systemic therapy for recurrent or metastatic adenoid cystic carcinoma remains limited, and durable disease control is difficult to achieve. We conducted a prospective, single-arm phase 2 trial of chidamide, a histone deacetylase inhibitor, plus cisplatin in 24 patients with recurrent or metastatic disease. Patients received a short chidamide lead-in followed by combination therapy for up to six cycles. The study did not meet its prespecified objective response target, with a confirmed objective response rate of 13.6% among 22 efficacy-evaluable patients. However, disease control was observed in 86.4% of patients, median progression-free survival was 17.9 months, and median overall survival was 40.3 months. Toxicity was manageable, with no treatment-related deaths. These findings support further evaluation of histone deacetylase inhibitor-platinum strategies as a disease-control approach in this rare cancer, while requiring validation in larger studies.",
  "abstract_shown": true,
  "affiliations": [],
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  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "Yizhen Liu"
    },
    {
      "name": "Guang-Liang Chen",
      "orcid": "0000-0002-3231-3576"
    },
    {
      "name": "Kai Xue"
    },
    {
      "name": "Qunling Zhang"
    },
    {
      "name": "Zuguang Xia"
    },
    {
      "name": "Dongmei Ji",
      "orcid": "0000-0003-0647-0153"
    },
    {
      "name": "Jia Jin"
    },
    {
      "name": "Fangfang Lv"
    },
    {
      "name": "Xiaojian Liu",
      "orcid": "0000-0002-8884-4448"
    },
    {
      "name": "Yulong Wang",
      "orcid": "0000-0002-3830-7257"
    },
    {
      "name": "Xiaonan Hong"
    },
    {
      "name": "Junning Cao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3ea00774bg58j.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117925",
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  "id": "3ea00774bg58j",
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  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03308-0",
  "language": "eng",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "heading",
      "Article"
    ],
    [
      "heading",
      "Dentistry"
    ],
    [
      "heading",
      "Health sciences"
    ],
    [
      "heading",
      "Internal medicine"
    ],
    [
      "heading",
      "Medical specialty"
    ],
    [
      "heading",
      "Medicine"
    ],
    [
      "heading",
      "Oncology"
    ],
    [
      "heading",
      "Therapeutics"
    ],
    [
      "openalex",
      "2746|Salivary Gland Tumors Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7223332410",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13720613/pdf/?tool=EBI",
  "pmcid": "PMC13720613",
  "pmid": "42964739",
  "published": "2026-10-23",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/3ea00774bg58j.ris",
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      "first_seen": "2026-10-30T12:17:16Z",
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      "first_seen": "2026-10-30T12:17:49Z",
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      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226033080"
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      "first_seen": "2026-10-31T12:21:37Z",
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    {
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      "url": "https://doi.org/10.1016/j.isci.2026.117925"
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  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "heading:Oncology",
      "subfield": "oncology"
    }
  ],
  "title": "A single arm phase II trial of chidamide plus cisplatin in advanced adenoid cystic carcinoma",
  "title_text": "A single arm phase II trial of chidamide plus cisplatin in advanced adenoid cystic carcinoma",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:27Z",
  "url": "https://research.draconitic.com/paper/3ea00774bg58j",
  "venue": "iScience",
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}