{
  "abstract": "Background and Objectives: Stroke and dementia are leading causes of death and disability worldwide, requiring enhanced preventive strategies. Glucagon-like peptide-1 receptor agonists (GLP-1RA), widely used for type 2 diabetes (T2D) and obesity, have demonstrated pleiotropic effects, including cardiovascular benefits, with mounting evidence also suggesting potential beneficial effects on brain health. The objective of this study was to investigate the genetically proxied effect of GLP-1RA on stroke, Alzheimer disease (AD), and related endophenotypes, in a cross-ancestry setting. Methods: gene expression. Primary outcomes were stroke (any, ischemic, cardioembolic, small vessel, large artery, and intracerebral hemorrhage) and AD. Secondary analyses included etiologic factors and endophenotypes of stroke and AD: heart failure, atrial fibrillation, MRI markers (white matter hyperintensity volume, perivascular space burden, and hippocampal volume), and CSF biomarkers (beta-amyloid, tau). Outcomes were stratified by ancestry and meta-analyzed. Results: < 0.05), on hippocampal perivascular space burden and CSF β-amyloid levels. Discussion: GLP-1RAs may confer protective effects against stroke (especially ischemic and cardioembolic) and AD risk, across ancestries. These findings warrant further investigation in experimental models and clinical trials to confirm benefits on brain health and understand underlying mechanisms.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 23,
  "authors": [
    {
      "name": "Ilana Caro-Châtelier"
    },
    {
      "name": "Muralidharan Sargurupremraj"
    },
    {
      "name": "Chengran Yang"
    },
    {
      "name": "Callistus Akinleye"
    },
    {
      "name": "David-Alexandre Trégouët"
    },
    {
      "name": "Rufus Olusola Akinyemi"
    },
    {
      "name": "Daichi Shigemizu"
    },
    {
      "name": "Motunrayo Coker"
    },
    {
      "name": "Joshua Akinyemi"
    },
    {
      "name": "Hemant Tiwari"
    },
    {
      "name": "Daniel Chasman"
    },
    {
      "name": "Bruce Ovbiagele"
    },
    {
      "name": "Hugues Chabriat"
    },
    {
      "name": "Vincent Mooser"
    },
    {
      "name": "Thierry Couffinhal"
    },
    {
      "name": "Aniket Mishra"
    },
    {
      "name": "Carlos Cruchaga"
    },
    {
      "name": "Christiane Reitz"
    },
    {
      "name": "Brian Kunkle"
    },
    {
      "name": "Yoichiro Kamatani"
    },
    {
      "name": "Mayowa Ojo Owolabi"
    },
    {
      "name": "Kamel Mohammedi"
    },
    {
      "name": "Stéphanie Debette"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3efga3dcp7as8.bib",
  "cited_by": 0,
  "doi": "10.1212/nxg.0000000000200425",
  "fulltext_url": null,
  "id": "3efga3dcp7as8",
  "issns": [
    "2376-7839"
  ],
  "landing_url": "https://hal.science/hal-05766858v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.gen"
    ],
    [
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      "hal",
      "2.sdv.sp.pharma"
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    [
      "openalex",
      "2737|Alzheimer's disease research and treatments"
    ]
  ],
  "openalex": "W7214398388",
  "pdf_url": "https://www.neurology.org/doi/pdf/10.1212/NXG.0000000000200425",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-25",
  "publisher": "American Academy of Neurology",
  "ris": "https://research.draconitic.com/paper/3efga3dcp7as8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:42Z",
      "native_id": "hal-05766858",
      "source": "hal",
      "url": "https://hal.science/hal-05766858v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.gen",
      "subfield": "genetics-genomics"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.spee",
      "subfield": "epidemiology-public-health"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.gen.gh",
      "subfield": "human-genetics"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.sp",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Genetic Insights Into Protective Effects of GLP-1 Receptor Agonists on Stroke and Alzheimer Disease Across Ancestries",
  "title_text": "Genetic Insights Into Protective Effects of GLP-1 Receptor Agonists on Stroke and Alzheimer Disease Across Ancestries",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:42Z",
  "url": "https://research.draconitic.com/paper/3efga3dcp7as8",
  "venue": "Neurology Genetics",
  "versions": []
}