{
  "abstract": "Osteoarthritis (OA) is a progressive joint disease characterized by cartilage destruction and is increasingly recognized as involving chronic low-grade inflammation. Synovitis contributes to OA progression through the production of proinflammatory mediators and reactive oxygen species (ROS). Sesamin, a lignan derived from sesame seeds, has demonstrated antioxidant and anti-inflammatory activities in various experimental models. However, the integrated effects of sesamin on oxidative stress, the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) pathway, and NLRP3 expression in interleukin-1β (IL-1β)-stimulated human synoviocytes remain insufficiently characterized. This study investigated the effects of sesamin on oxidative stress and inflammatory responses and examined the involvement of the Nrf2/HO-1 pathway and NLRP3 expression in IL-1β-stimulated human SW982 synovial cells. Sesamin (2.5–10 μM) significantly reduced IL-1β-induced intracellular ROS levels, with a 60% reduction observed at the highest concentration. At 10 μM, sesamin increased Nrf2 nuclear translocation approximately 2-fold and HO-1 expression by 1.5-fold compared with the IL-1β control. In contrast, sesamin reduced NLRP3 expression to approximately 0.5-fold of the IL-1β control. Sesamin also reduced the levels of IL-1β, IL-6, and cyclooxygenase-2 (COX-2) by approximately 50%, 12%, and 40%, respectively. These findings demonstrate that sesamin attenuates IL-1β-induced oxidative and inflammatory responses in human synovial cells, accompanied by activation of the Nrf2/HO-1 antioxidant pathway and reduced NLRP3 expression. Collectively, these findings support further investigation of sesamin as a potential therapeutic modulator of synovitis-associated mechanisms in OA.",
  "abstract_shown": true,
  "affiliations": [
    "Chiang Mai University , , ,",
    "Mahidol University , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Benjawan Wudtiwai"
    },
    {
      "affs": [
        1
      ],
      "name": "Atitaya Wayupat"
    },
    {
      "affs": [
        1
      ],
      "name": "Aitthiphon Chongchai"
    },
    {
      "affs": [
        0
      ],
      "name": "Prachya Kongtawelert",
      "orcid": "0000-0002-5963-2796"
    },
    {
      "affs": [
        0
      ],
      "name": "Peraphan Pothacharoen",
      "orcid": "0000-0002-8560-553X"
    },
    {
      "affs": [
        0
      ],
      "name": "Thanyaluck Phitak",
      "orcid": "0000-0002-7457-6737"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3esb60x01bcgr.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.6c08490",
  "fulltext_url": "https://europepmc.org/articles/PMC13689143",
  "id": "3esb60x01bcgr",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://pubs.acs.org/acsodf/article/11/41/63908/5446723/Sesamin-Attenuates-Interleukin-1-Induced",
  "language": "eng",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2745|Osteoarthritis Treatment and Mechanisms"
    ]
  ],
  "openalex": "W7220943023",
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/acsomega.6c08490",
  "pmcid": "PMC13689143",
  "pmid": "42923549",
  "published": "2026-10-08",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/3esb60x01bcgr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:39Z",
      "native_id": "10.1021/acsomega.6c08490",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/11/41/63908/5446723/Sesamin-Attenuates-Interleukin-1-Induced"
    },
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42923549",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42923549"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2745|Osteoarthritis Treatment and Mechanisms",
      "subfield": "general"
    }
  ],
  "title": "Sesamin Attenuates Interleukin-1β-Induced Inflammation in Human Synovial Cells: Involvement of the Nrf2/HO-1 Pathway and NLRP3 Expression",
  "title_text": "Sesamin Attenuates Interleukin-1β-Induced Inflammation in Human Synovial Cells: Involvement of the Nrf2/HO-1 Pathway and NLRP3 Expression",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:33Z",
  "url": "https://research.draconitic.com/paper/3esb60x01bcgr",
  "venue": "ACS Omega",
  "versions": []
}