{
  "abstract": "Objective: Cushing’s syndrome (CS) is associated with marked impairment in quality of life (QoL). This analysis aimed to comprehensively describe QoL impairment in participants of the PROMPT study using two validated instruments: the CushingQoL and the Tübingen Cushing’s Disease Quality of Life Inventory (CD-25).\n\nMethods: Cross-sectional analysis used baseline questionnaires from PROMPT (NCT02297945), a prospective study of metyrapone in 49 adults with confirmed endogenous CS. Item- and domain-level analyses were conducted for the CushingQoL (0-100; higher = better QoL) and CD-25 (0-100; higher = worse QoL). Subgroups: sex (15 males, 34 females) and biochemical UFC severity (31 moderate and 16 severe).\n\nResults: Patients reported substantial impairment in QoL. The mean CushingQoL score was 41.2 (95%CI 35.6-46.7), with greater physical (36.8) than psychosocial (45.5) burden. The CD-25 score was 39.8 (95%CI 32.7-46.9), with bodily restrictions (48.6) and eating behaviour (44.7) most severely affected. Worry about future health (75.5%) and physical appearance (73.5%) were the most prevalent individual concerns. The two instruments were strongly inversely correlated (r= −0.81, p<0.001). Females reported clinically worse psychosocial QoL compared with males (CushingQoL psychosocial: 41.7 vs 54.2, −12.2 points; CD-25 depression: 39.5 vs 26.9, + 12.6 points), despite similar biochemical severity. No meaningful differences in overall QoL scores were observed between patients with moderate versus severe hypercortisolism.\n\nConclusions: Uncontrolled CS is associated with profound multidomain QoL impairment dominated by psychological distress, largely independent of biochemical disease severity. Women reported clinically meaningful worse psychosocial outcomes than men. Disease-specific, item-level QoL assessment may add information not captured by biochemical parameters in patients with active CS.",
  "abstract_shown": true,
  "affiliations": [
    "Endocrinology Unit, Department of Medicine, Hospital-University",
    "National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health",
    "Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg",
    "Medicover Oldenburg MVZ",
    "Department of Internal Medicine, University Medical School",
    "Hôpital Universitaire de Bruxelles Hôpital Erasme, Université Libre de Bruxelles",
    "Department of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy and Cluj County Emergency Hospital",
    "Department of Endocrinology, Oncologic Endocrinology and Nuclear Medicine, University Hospital in Krakow",
    "Endocrinology Department, Jagiellonian University Medical College",
    "Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie National Research Institute of Oncology",
    "Department of Endocrinology and Nutrition, UCLouvain Hospital Saint-Luc",
    "Department of Medicine 4, Klinikum der Universität, Ludwig-Maximilians-Universität München",
    "Endocrinology Department, Clinica San Carlo, Paderno Dugnano",
    "Endocrinology Unit, Azienda Socio-Sanitaria Territoriale (ASST) Grande Ospedale Metropolitano Niguarda",
    "Division of Endocrinology and Metabolism, Department of Internal Medicine, Ondokuz Mayis University",
    "Department of Endocrinology IV, “C.I Parhon”, National Institute of Endocrinology, “D. Davila” University of Medicine and Pharmacy",
    "Endocrinology Department, University Hospital",
    "Department of Endocrinology and Internal Medicine, Medical University Wroclaw",
    "Endocrinology Clinic, Istituto Auxologico Italiano",
    "Department of Endocrinology, Diabetes and Metabolism, University Hospital Essen",
    "Department of Biological and Clinical Sciences, University of Turin",
    "Endocrinology Department, Hospital Clinic, University of Barcelona",
    "Department of Clinical and Biological Sciences, Internal Medicine, San Luigi Gonzaga Hospital",
    "Esteve S.A.",
    "Biostatistics and Clinical Epidemiology Service, National Institutes of Health Clinical Center, National Institute of Health",
    "Department of Internal Medicine and Oncology, Semmelweis University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 28,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Carla Scaroni"
    },
    {
      "affs": [
        1
      ],
      "name": "Lynnette K. Nieman"
    },
    {
      "affs": [
        0
      ],
      "name": "Marco Boscaro"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Timo Deutschbein"
    },
    {
      "affs": [
        4
      ],
      "name": "Emese Mezôsi"
    },
    {
      "affs": [
        5
      ],
      "name": "Natacha Driessens"
    },
    {
      "affs": [
        6
      ],
      "name": "Carmen E. Georgescu"
    },
    {
      "affs": [
        7
      ],
      "name": "Marcin Motyka"
    },
    {
      "affs": [
        8
      ],
      "name": "Alicja Hubalewska-Dydejczyk"
    },
    {
      "affs": [
        9
      ],
      "name": "Barbara Jarzab"
    },
    {
      "affs": [
        10
      ],
      "name": "Dominique Maiter"
    },
    {
      "affs": [
        11
      ],
      "name": "Martin Reincke"
    },
    {
      "affs": [
        12
      ],
      "name": "Paola Loli"
    },
    {
      "affs": [
        13
      ],
      "name": "Benedetta Zampetti"
    },
    {
      "affs": [
        14
      ],
      "name": "Aysegul Atmaca"
    },
    {
      "affs": [
        15
      ],
      "name": "Corin Badiu"
    },
    {
      "affs": [
        16
      ],
      "name": "Albert Beckers"
    },
    {
      "affs": [
        17
      ],
      "name": "Marek Bolanowski"
    },
    {
      "affs": [
        18
      ],
      "name": "Francesco Cavagnini"
    },
    {
      "affs": [
        19
      ],
      "name": "Nicole Unger"
    },
    {
      "affs": [
        20
      ],
      "name": "Roberta Giordano"
    },
    {
      "affs": [
        21
      ],
      "name": "Felicia Alexandra Hanzu"
    },
    {
      "affs": [
        22
      ],
      "name": "Massimo Terzolo"
    },
    {
      "affs": [
        23
      ],
      "name": "Arnau Domenech"
    },
    {
      "affs": [
        23
      ],
      "name": "Myriam Bou Nader"
    },
    {
      "affs": [
        24
      ],
      "name": "Ninet Sinaii"
    },
    {
      "affs": [
        25
      ],
      "name": "Judit Tőke"
    },
    {
      "affs": [
        25
      ],
      "name": "Miklós Tóth"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3f1z11vshkv8h.bib",
  "cited_by": 0,
  "doi": "10.3389/fendo.2026.1964012",
  "fulltext_url": null,
  "id": "3f1z11vshkv8h",
  "issns": [
    "1664-2392"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1964012/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-05",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/3f1z11vshkv8h.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T12:21:29Z",
      "native_id": "10.3389/fendo.2026.1964012",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1964012/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:1664-2392",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Quality of life burden in Cushing’s syndrome: baseline results from the PROMPT study",
  "title_text": "Quality of life burden in Cushing’s syndrome: baseline results from the PROMPT study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T00:21:25Z",
  "url": "https://research.draconitic.com/paper/3f1z11vshkv8h",
  "venue": "Frontiers in Endocrinology",
  "versions": []
}