{
  "abstract": "Background\n\nTo investigate the cross-sectional association between hypertension and OCTA-derived retinal microvascular characteristics and to assess whether deep capillary plexus perfusion area (DCP-PA) provides additional explanatory information for concurrent visual acuity in retinal vein occlusion (RVO).Methods\n\nThis retrospective secondary cross-sectional analysis included 88 RVO-affected eyes from 88 patients. Best-corrected visual acuity (BCVA) and swept-source OCTA were assessed at the same visit. Multivariable linear regression evaluated associations between hypertension and six OCTA outcomes after adjustment for age, sex, RVO subtype, and hyperlipidemia, with Benjamini-Hochberg false-discovery-rate (FDR) correction. The association between DCP-PA and concurrent logMAR BCVA was assessed using a clinical-structural model including age, sex, RVO subtype, hypertension, hyperlipidemia, and total retinal thickness (TRT), followed by an extended model incorporating DCP-PA.Results\n\nHypertension was associated with lower DCP-PA (β=-1.71; 95% CI, -2.85 to -0.57; FDR-adjusted P=0.011) and lower DCP vessel length density (β=-3.29; 95% CI, -5.48 to -1.09; FDR-adjusted P=0.011). Lower DCP-PA remained independently associated with worse concurrent visual acuity after adjustment for clinical factors and TRT (β=-0.12 per mm²; 95% CI, -0.16 to -0.08; P<0.001). Hyperlipidemia was also associated with worse visual acuity (β=0.34; 95% CI, 0.18 to 0.49; P<0.001). Adding DCP-PA increased adjusted R ² from 0.40 to 0.59 and reduced AIC from 94.60 to 61.99 (partial F=38.54; P<0.001). No significant interaction was observed between DCP-PA and RVO subtype (P=0.353).Conclusions\n\nHypertension was associated with reduced deep retinal perfusion in RVO. Lower DCP-PA was independently associated with worse concurrent visual acuity and provided additional explanatory information beyond clinical factors and retinal thickness. These cross-sectional findings do not establish causality or prospective prognostic value.",
  "abstract_shown": true,
  "affiliations": [
    "Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, 510060, People's Republic of China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jinlian Zhan"
    },
    {
      "affs": [
        0
      ],
      "name": "Yanting Lai"
    },
    {
      "affs": [
        0
      ],
      "name": "Haichun Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Lin Lu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiujuan Zhao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3f3ddmg0zng1d.bib",
  "cited_by": 0,
  "doi": "10.2147/opth.s652471",
  "fulltext_url": "https://europepmc.org/articles/PMC13682290",
  "id": "3f3ddmg0zng1d",
  "issns": [
    "1177-5467",
    "1177-5483"
  ],
  "landing_url": "https://europepmc.org/article/MED/42903718",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2731|Retinal Diseases and Treatments"
    ]
  ],
  "openalex": "W7222620722",
  "pdf_url": "https://europepmc.org/articles/PMC13682290?pdf=render",
  "pmcid": "PMC13682290",
  "pmid": "42903718",
  "published": "2026-10-16",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/3f3ddmg0zng1d.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42903718",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42903718"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2731|Retinal Diseases and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Hypertension, Deep Retinal Perfusion, and Concurrent Visual Acuity in Retinal Vein Occlusion: A Cross-Sectional OCTA Study.",
  "title_text": "Hypertension, Deep Retinal Perfusion, and Concurrent Visual Acuity in Retinal Vein Occlusion: A Cross-Sectional OCTA Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/3f3ddmg0zng1d",
  "venue": "Clinical ophthalmology (Auckland, N.Z.)",
  "versions": []
}