{
  "abstract": "A general method to generate α-alkoxyalkyl radicals from pinacol boronic ester precursors (R-Bpin) has been developed. These radical precursors are stable in air, easy to prepare, and readily accessible via Matteson homologation followed by a 1,2-metallate shift with a broad range of metal alkoxides. The key step is a transesterification with catechol methyl borate (MeOBcat), converting the inert Bpin species into a radical-active Bcat intermediate, which then undergoes nucleohomolytic substitution at boron to release the desired radical. This approach is practical, scalable (demonstrated at 4 mmol scale), and broadly applicable. It avoids toxic reagents and expensive photocatalysts, offering a straightforward route to ether-containing molecules relevant to the synthesis of natural product and bioactive compounds.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Emy André-Joyaux"
    },
    {
      "name": "Lise Benoist"
    },
    {
      "name": "Agathe Fayolle"
    },
    {
      "name": "Fabrice Dénès"
    },
    {
      "name": "Philippe Renaud"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3fb6612q5kdk6.bib",
  "cited_by": 1,
  "doi": "10.1039/d6qo01025c",
  "fulltext_url": null,
  "id": "3fb6612q5kdk6",
  "issns": [
    "2052-4110",
    "2052-4129"
  ],
  "landing_url": "https://nantes-universite.hal.science/hal-05853697v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "openalex",
      "1605|Radical Photochemical Reactions"
    ]
  ],
  "openalex": "W7213279916",
  "pdf_url": "https://nantes-universite.hal.science/hal-05853697/document",
  "pmcid": null,
  "pmid": "42774905",
  "published": "2026-09-15",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/3fb6612q5kdk6.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:20:25Z",
      "native_id": "hal-05853697",
      "source": "hal",
      "url": "https://nantes-universite.hal.science/hal-05853697v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Radical Photochemical Reactions",
      "subfield": "organic"
    }
  ],
  "title": "A unified strategy for α-alkoxyalkyl radical generation via pinacol boronic ester precursors",
  "title_text": "A unified strategy for α-alkoxyalkyl radical generation via pinacol boronic ester precursors",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:20:25Z",
  "url": "https://research.draconitic.com/paper/3fb6612q5kdk6",
  "venue": "Organic Chemistry Frontiers",
  "versions": []
}