{
  "abstract": "Dimethyl(phenyl)(2,3,3-trifluoroallyl)silane, the defluorosilylation product of HFO-1234yf, reacts with KHMDS to form 3,3-difluoro-1-dimethyl(phenyl)silylpropyne. The mechanism of this transformation was rationalized through DFT calculations. Deprotonation and subsequent β-fluoride elimination leads to an allene intermediate. A base-catalyzed 1,3-proton migration from the allene then results in the difluoromethylated alkyne product. This alkynyl silane can undergo transmetalation with NHC-ligated Group 11 transition metal chloride complexes to form novel metal acetylide compounds with a 3,3-difluoropropynyl motif.",
  "abstract_shown": true,
  "affiliations": [
    "Molecular Sciences Research Hub, Imperial College London, 82 Wood Lane, London, UK, W12 0BZ"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Georgina Rai"
    },
    {
      "affs": [
        0
      ],
      "name": "Sarah Brock"
    },
    {
      "affs": [
        0
      ],
      "name": "Zachary Bub"
    },
    {
      "affs": [
        0
      ],
      "name": "Benedek Stadler"
    },
    {
      "name": "Mark Crimmin",
      "orcid": "0000-0002-9339-9182"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3fpcx27ta0n1g.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15010606/v1",
  "fulltext_url": null,
  "id": "3fpcx27ta0n1g",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010606/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3003|Fluorine in Organic Chemistry"
    ]
  ],
  "openalex": "W7222450171",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010606/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-16",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/3fpcx27ta0n1g.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.26434/chemrxiv.15010606",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010606/v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3003|Fluorine in Organic Chemistry",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "HFO-1234yf as a Source of the 3,3-Difluoropropynyl Group",
  "title_text": "HFO-1234yf as a Source of the 3,3-Difluoropropynyl Group",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/3fpcx27ta0n1g",
  "venue": "ChemRxiv",
  "versions": []
}