{
  "abstract": "Background: Bladder paraganglioma is a rare non-epithelial neuroendocrine tumor. Catecholamine release may cause micturition-related headache, palpitations, sweating, paroxysmal hypertension, or syncope, but cases without typical symptoms can be difficult to recognize before surgery. Complete surgical excision remains the mainstay of treatment.\n\nCase presentation: A 75-year-old woman was admitted after two bladder lesions were detected. She had no hematuria, lower urinary tract symptoms, or micturition-related headache, palpitations, sweating, or paroxysmal hypertension. Contrast-enhanced CT showed two hypervascular nodules near the bladder neck and on the left posterior wall, measuring 12 × 14 mm and 6 × 9 mm, respectively. Twenty-four-hour urinary free catecholamines were within the reference ranges. Plasma free normetanephrine was mildly elevated at 0.96 nmol/L (upper reference limit, 0.71 nmol/L; approximately 1.35 × ULN) when measured by LC-MS/MS under standardized sampling conditions, whereas plasma metanephrine and 3-methoxytyramine remained within their reference ranges. This profile was considered consistent with a clinically silent but mildly biochemically functional tumor. The patient underwent pneumovesicoscopic en bloc resection. Histopathology confirmed multifocal bladder paraganglioma confined to the submucosa, with negative surgical margins, a Ki-67 proliferation index <1%, and retained SDHB expression. Recovery was uneventful, and cystoscopy showed no recurrence at 12 months.\n\nConclusions: Bladder paraganglioma should be considered in a hypervascular submucosal bladder mass with intact overlying mucosa even when typical catecholamine-related symptoms are absent. This single case supports the technical feasibility of pneumovesicoscopic en bloc resection for selected localized lesions, but the 12-month follow-up is insufficient to establish comparative effectiveness or long-term oncologic safety.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Urology, First People's Hospital of Kunshan, Kunshan, China"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Bing Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yu Hong"
    },
    {
      "affs": [
        0
      ],
      "name": "Tianhai Liao"
    },
    {
      "affs": [
        0
      ],
      "name": "Dingli Hu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yunlong Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3g17tq3cyz9t0.bib",
  "cited_by": 0,
  "doi": "10.3389/fmed.2026.1992514",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13730866/",
  "id": "3g17tq3cyz9t0",
  "issns": [
    "2296-858X"
  ],
  "landing_url": "https://doi.org/10.3389/fmed.2026.1992514",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "openalex",
      "2746|Adrenal and Paraganglionic Tumors"
    ]
  ],
  "openalex": "W7223153227",
  "pdf_url": "https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1992514/pdf",
  "pmcid": "PMC13730866",
  "pmid": "42984550",
  "published": "2026-10-21",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/3g17tq3cyz9t0.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:23:50Z",
      "native_id": "PMC13730866",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fmed.2026.1992514"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Adrenal and Paraganglionic Tumors",
      "subfield": "surgery"
    }
  ],
  "title": "Pneumovesicoscopic en bloc resection of multifocal bladder paraganglioma: a case report",
  "title_text": "Pneumovesicoscopic en bloc resection of multifocal bladder paraganglioma: a case report",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:10Z",
  "url": "https://research.draconitic.com/paper/3g17tq3cyz9t0",
  "venue": "Frontiers in Medicine",
  "versions": []
}