{
  "abstract": "Objective:: The current research aimed to explore the molecular pathway of sesamin in controlling the Wnt/β-catenin signaling pathway and associated oncogenic regulators in ovarian cancer cells.\n\nMethods:: Molecular docking was conducted to assess sesamin’s binding activity toward major signaling proteins (Wnt, β-catenin, GSK3β, TGF-β). Functional confirmation was performed using quantitative PCR (qPCR) to quantify gene expression following a 48-hour treatment of ovarian cancer cells with sesamin.\n\nResult:: Docking simulations revealed strong binding affinities, particularly with Wnt (−9.19 kcal/mol), supported by hydrogen bond interactions. qPCR results showed significant downregulation of Wnt (50%), TGF-β (40%), GSK3β (25%), and β-catenin transcripts compared to the control (p < 0.001).\n\nConclusion:: Sesamin potently inhibits several oncogenic regulators within the Wnt/β-catenin pathway, positioning it as a potential multi-target natural therapeutic for ovarian cancer. These findings support sesamin as a promising candidate for further preclinical and clinical investigation, particularly as an adjuvant therapy to overcome drug resistance and limit tumor progression.",
  "abstract_shown": true,
  "affiliations": [
    "Central Research Laboratory, Meenakshi Ammal Dental College, Meenakshi Academy of Higher Education and Research, Deemed to be University, Chennai-600095, India.",
    "Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077, India.",
    "Meenakshi Academy of Higher Education and Research, Deemed to be University. West K. K. Nagar, Chennai - 600078, Tamil Nadu, India."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Heera Maheswari Jayaveeran"
    },
    {
      "affs": [
        0
      ],
      "name": "Ponnulakshmi Rajagopal"
    },
    {
      "affs": [
        0
      ],
      "name": "Manju Parthiban"
    },
    {
      "affs": [
        1
      ],
      "name": "Selvaraj Jayaraman"
    },
    {
      "affs": [
        2
      ],
      "name": "Sureka Varalakshmi V"
    },
    {
      "affs": [
        2
      ],
      "name": "Krithika Chandrasekaran"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3gejbaar5hr2h.bib",
  "cited_by": 0,
  "doi": "10.31557/apjcp.2026.27.6.2149",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13726542/",
  "id": "3gejbaar5hr2h",
  "issns": [
    "1513-7368",
    "2476-762X"
  ],
  "landing_url": "https://doi.org/10.31557/apjcp.2026.27.6.2149",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "1312|Wnt/β-catenin signaling in development and cancer"
    ]
  ],
  "openalex": "W7165927141",
  "pdf_url": "https://journal.waocp.org/article_92235_2198b4118470e2f9e9555536f3b4b555.pdf",
  "pmcid": "PMC13726542",
  "pmid": "42345162",
  "published": "2026-06-19",
  "publisher": "Shahid Beheshti University of Medical Sciences",
  "ris": "https://research.draconitic.com/paper/3gejbaar5hr2h.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T12:22:51Z",
      "native_id": "PMC13726542",
      "source": "pmc",
      "url": "https://doi.org/10.31557/apjcp.2026.27.6.2149"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Wnt/β-catenin signaling in development and cancer",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Sesamin Suppresses Ovarian Cancer Progression via Modulation of Wnt/β-Catenin and Associated Oncogenic Pathways",
  "title_text": "Sesamin Suppresses Ovarian Cancer Progression via Modulation of Wnt/β-Catenin and Associated Oncogenic Pathways",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:28Z",
  "url": "https://research.draconitic.com/paper/3gejbaar5hr2h",
  "venue": "Asian Pacific Journal of Cancer Prevention : APJCP",
  "versions": []
}